{"id":"W4299530113","doi":"10.17615/kssb-fk64","title":"Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Mitacs; American Lebanese Syrian Associated Charities; Howard Hughes Medical Institute; Biogen; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; Austrian Science Fund; Takeda Oncology; U.S. Department of Energy","keywords":"Elongation; Ubiquitin; Dual (grammatical number); Ring (chemistry); Chain (unit); Chemistry; Cell biology; Biology; Biochemistry; Physics; Materials science; Gene; Art","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109303,0.0002086848,0.00010069,0.0001727415,0.0002872936,0.0004462784,0.0002004818,0.0002162006,0.0008507383],"category_scores_gemma":[0.000137565,0.0001367839,0.0001160357,0.0001496361,0.0003196979,0.0003246469,0.0002943203,0.0002559293,0.0002085104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006634526,"about_ca_system_score_gemma":0.0002690027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000965433,"about_ca_topic_score_gemma":0.001837165,"domain_scores_codex":[0.9999174,0.000008973612,0.000005036429,0.00002154991,0.00002262026,0.00002441536],"domain_scores_gemma":[0.9999344,0.000008225888,0.00002192274,0.000008986098,0.00001166591,0.00001474107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006481102,0.000006091292,0.0005122368,0.00001277772,0.000002586953,0.00007441435,0.00001957109,0.0002877685,0.9964963,0.0008912732,0.00005331194,0.00157877],"study_design_scores_gemma":[0.000007572555,0.00001775497,0.006567187,0.0000036578,0.000005015981,0.0002116546,0.00003279708,0.001639223,0.9896809,0.0002605969,0.001568698,0.000004907774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933215,0.000715744,0.003871302,0.0000519877,0.000008070668,0.000005505869,0.00008814206,0.00008172544,0.001856048],"genre_scores_gemma":[0.9973119,0.0003060532,0.001367833,0.0000146889,0.000001893529,0.000004108083,0.00004928814,0.00001402507,0.0009302233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000965433,"threshold_uncertainty_score":0.004813731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008200921061937075,"score_gpt":0.1952229274891398,"score_spread":0.1870220064272028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}