{"id":"W4299556061","doi":"10.1136/annrheumdis-2022-eular.1286","title":"POS0288 A CANADIAN RETROSPECTIVE CHART REVIEW EVALUATING CONCOMITANT METHOTREXATE DE-ESCALATION PATTERNS IN RA PATIENTS TREATED WITH BIOLOGIC OR TARGETED SYNTHETIC DMARDS","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"The Scarborough Hospital; Université Laval; University of Alberta; University of Saskatchewan; ABB (Canada); University of Toronto","funders":"University of Twente; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Amsterdam University Medical Centers; Bristol-Myers Squibb; National Institutes of Health; Universiteit van Amsterdam; National Institute of Allergy and Infectious Diseases; Amgen","keywords":"Medicine; Methotrexate; Rheumatoid arthritis; Tolerability; Concomitant; Internal medicine; Prednisone; Regimen; Cohort; Retrospective cohort study; Antifolate; Surgery; Adverse effect; Antimetabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000882017,0.0003125044,0.0005407337,0.003742867,0.001523908,0.001165354,0.0008881679,0.0005185038,0.003648683],"category_scores_gemma":[0.006211236,0.0004263489,0.0005493033,0.008178579,0.0004931035,0.0004413364,0.000498945,0.000506799,0.0003414176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01107666,"about_ca_system_score_gemma":0.02560254,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8653907,"about_ca_topic_score_gemma":0.8959029,"domain_scores_codex":[0.9975847,0.0002172528,0.000413409,0.0003860857,0.001018522,0.0003799681],"domain_scores_gemma":[0.9906087,0.001019429,0.003787696,0.0002932004,0.003526402,0.0007645965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002074269,0.00002800498,0.9905346,0.0002081873,0.00008600669,0.0008594778,0.0002556227,0.00005257629,0.0003672018,0.0001068931,0.002315502,0.004978521],"study_design_scores_gemma":[0.00003088332,0.00006752244,0.993046,0.0001650811,0.00009490323,0.001592133,0.000588347,0.0001471281,0.0002190495,0.00001473322,0.004014802,0.00001951864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528532,0.006551212,0.0002679753,0.0005189594,0.00004605245,0.0003568845,0.02675322,0.00004126268,0.01261126],"genre_scores_gemma":[0.9898177,0.002054827,0.0004994193,0.000389526,0.00002416089,0.00008253256,0.006205667,0.0000159901,0.0009101455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1346093,"threshold_uncertainty_score":0.270804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04659313253689018,"score_gpt":0.3392946291144187,"score_spread":0.2927014965775285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}