{"id":"W4299598591","doi":"10.17615/2qt3-6p69","title":"Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agència de Gestió d'Ajuts Universitaris i de Recerca; Leukemia and Lymphoma Research; National Health and Medical Research Council; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Pittsburgh; Stockholms Läns Landsting; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Bundesministerium für Bildung und Forschung; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Instituto de Salud Carlos III; Ohio State University; Wake Forest University; National Natural Science Foundation of China; University of Southern California; Cancer Research UK; Division of Cancer Prevention, National Cancer Institute; University of Sydney; U.S. Department of Veterans Affairs; Compagnia di San Paolo; European Commission; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; Health Research Board; National Cancer Research Institute; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Memorial Sloan-Kettering Cancer Center; Yale University; Karolinska Institutet; Utah State University; Cancer Council Victoria; Utah Department of Health; Brigham and Women's Hospital","keywords":"Chronic lymphocytic leukemia; Genetics; Biology; Genome-wide association study; Computational biology; Leukemia; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996182,0.0002924463,0.001967323,0.0002704552,0.0001263127,0.00007033789,0.000264425,0.0001598184,0.0003350248],"category_scores_gemma":[0.006308305,0.0002242479,0.001459814,0.001327765,0.0002492896,0.0004319765,0.0002238723,0.0001494473,0.00002907416],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.04995957,"about_ca_system_score_gemma":0.01927566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823574,"about_ca_topic_score_gemma":0.00009475309,"domain_scores_codex":[0.9973397,0.00009708816,0.0006904792,0.0005253617,0.0008188331,0.0005285819],"domain_scores_gemma":[0.9939272,0.004687354,0.0003748774,0.0004721704,0.0003171337,0.0002212759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00169743,0.0000702723,0.009848762,0.002782577,0.8844275,0.0000568262,0.01150077,0.05036089,0.001136437,0.007000698,0.03096178,0.000156063],"study_design_scores_gemma":[0.03172864,0.001416421,0.002186473,0.00003398183,0.6027543,0.00000367263,0.004181728,0.2914419,0.03437694,0.0032535,0.02780738,0.0008150485],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7581395,0.1588926,0.02842538,0.03864098,0.0005429337,0.008921013,0.002063473,0.001124986,0.003249112],"genre_scores_gemma":[0.9871984,0.0002424808,0.00420737,0.002695612,0.000295944,0.0002211425,0.0004993249,0.00006904817,0.004570709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2816732,"threshold_uncertainty_score":0.9862841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1363682759606036,"score_gpt":0.3247635267741321,"score_spread":0.1883952508135285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}