{"id":"W4299598591","doi":"10.17615/2qt3-6p69","title":"Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agència de Gestió d'Ajuts Universitaris i de Recerca; Leukemia and Lymphoma Research; National Health and Medical Research Council; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Pittsburgh; Stockholms Läns Landsting; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Bundesministerium für Bildung und Forschung; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Instituto de Salud Carlos III; Ohio State University; Wake Forest University; National Natural Science Foundation of China; University of Southern California; Cancer Research UK; Division of Cancer Prevention, National Cancer Institute; University of Sydney; U.S. Department of Veterans Affairs; Compagnia di San Paolo; European Commission; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; Health Research Board; National Cancer Research Institute; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Memorial Sloan-Kettering Cancer Center; Yale University; Karolinska Institutet; Utah State University; Cancer Council Victoria; Utah Department of Health; Brigham and Women's Hospital","keywords":"Chronic lymphocytic leukemia; Genetics; Biology; Genome-wide association study; Computational biology; Leukemia; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005867794,0.001443748,0.002966179,0.003172657,0.0006595778,0.002062681,0.0008748657,0.0009223823,0.002089196],"category_scores_gemma":[0.01163348,0.000626891,0.00860964,0.005305158,0.000377743,0.0006015199,0.001182467,0.001142127,0.0002263716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005041627,"about_ca_system_score_gemma":0.0007367929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003921754,"about_ca_topic_score_gemma":0.007108154,"domain_scores_codex":[0.994464,0.00258463,0.0005694589,0.00155651,0.0005605819,0.0002647759],"domain_scores_gemma":[0.9935369,0.003831786,0.0009498552,0.001131295,0.0003167964,0.0002333005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005415914,0.00005651342,0.5749335,0.003065323,0.3664409,0.001071147,0.0001616721,0.00251512,0.009025192,0.0005512385,0.002297237,0.03446635],"study_design_scores_gemma":[0.0009186846,0.0007113941,0.5611367,0.0007614826,0.417269,0.001661668,0.0002381842,0.00507991,0.002557239,0.002673207,0.006921989,0.00007053382],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7136226,0.2575721,0.01806826,0.001854724,0.0005500938,0.00009513582,0.005271118,0.0006158634,0.002350239],"genre_scores_gemma":[0.9792736,0.01584423,0.002520798,0.0003317154,0.0001556361,0.00005747624,0.001395167,0.00005943129,0.0003619601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005867794,"threshold_uncertainty_score":0.0310322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1363682759606036,"score_gpt":0.3247635267741321,"score_spread":0.1883952508135285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}