{"id":"W4299598833","doi":"10.17615/14mj-1p71","title":"CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Damon Runyon Cancer Research Foundation; Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Cancer Society Research Institute; U.S. Department of Health and Human Services; National Institutes of Health; Sociedad Española de Oncología Médica; Ministerio de Economía y Competitividad; Ontario Institute for Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Division of Cancer Prevention, National Cancer Institute","keywords":"Progestogen; CYP24A1; Colorectal cancer; Medicine; Oncology; Internal medicine; Cancer; Estrogen; Vitamin D and neurology; Calcitriol receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001073372,0.0005088584,0.000629287,0.0006857027,0.0002875822,0.0007819888,0.0003836515,0.0007241067,0.004080387],"category_scores_gemma":[0.003167856,0.0002771401,0.001312797,0.001725753,0.0003306712,0.0002103768,0.0002654266,0.0005006173,0.0003958708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067721,"about_ca_system_score_gemma":0.0001912494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001670336,"about_ca_topic_score_gemma":0.00131342,"domain_scores_codex":[0.9988594,0.0004240852,0.0001272014,0.0003844962,0.0001297471,0.00007501528],"domain_scores_gemma":[0.9982034,0.0007647365,0.0006769629,0.0001904482,0.00007022627,0.00009426404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005650636,0.00009411647,0.9541353,0.000257197,0.005293073,0.001055525,0.0001366593,0.0007114732,0.01722329,0.0001723539,0.0004195381,0.01485076],"study_design_scores_gemma":[0.0001559354,0.0004770326,0.991724,0.00002498962,0.001870397,0.001953794,0.00003507564,0.0009937735,0.001548234,0.0002838889,0.0009189417,0.00001395295],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943041,0.003092869,0.000686816,0.0001360276,0.0000225526,0.0000235052,0.001037827,0.00003376876,0.0006625677],"genre_scores_gemma":[0.9990181,0.0002035312,0.0003089854,0.00004415162,0.00002142545,0.00001221883,0.0002145529,0.00001058301,0.0001664337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004080387,"threshold_uncertainty_score":0.01365024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07612360716062051,"score_gpt":0.2535229267971177,"score_spread":0.1773993196364972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}