{"id":"W4300002445","doi":"10.1002/cmdc.202200399","title":"Effects of the 5′‐Triphosphate Metabolites of Ribavirin, Sofosbuvir, Vidarabine, and Molnupiravir on CTP Synthase Catalysis and Filament Formation: Implications for Repurposing Antiviral Agents against SARS‐CoV‐2","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Research Nova Scotia; IWK Health Centre; Dalhousie University; Dalhousie Medical Research Foundation; QEII Foundation; Mitacs","keywords":"Biochemistry; Sofosbuvir; ATP synthase; Nucleotide; Chemistry; Enzyme; Nucleotide salvage; Allosteric regulation; Biology; Ribavirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955989,0.000142282,0.0002025652,0.00003965357,0.0001714598,0.00001330956,0.0002066898,0.00006695703,0.000001064759],"category_scores_gemma":[0.0001733266,0.0001165636,0.0001316984,0.000157399,0.0001729014,0.000006659128,0.0004057644,0.00009992821,1.40534e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001869646,"about_ca_system_score_gemma":0.00003523416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007400088,"about_ca_topic_score_gemma":0.000001090976,"domain_scores_codex":[0.9990308,0.00005341901,0.0002493203,0.0003055485,0.0001622108,0.0001987531],"domain_scores_gemma":[0.9993138,0.0000487871,0.0001608184,0.0003509006,0.00007803977,0.00004767024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000983816,0.0001521791,0.0002240895,0.0002417981,0.00007336912,4.159994e-7,0.0000580676,0.000002856919,0.9896253,0.0001164021,0.0005861724,0.008820931],"study_design_scores_gemma":[0.0007781471,0.0001565762,0.001174441,0.00002254334,0.00007336913,0.000004335117,0.00003365696,0.00006348849,0.9935236,0.0001399428,0.003911551,0.0001183492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995052,0.003317299,0.0003165202,0.0003964601,0.00002849318,0.0006140204,0.000121267,0.000004727131,0.0001491628],"genre_scores_gemma":[0.9986548,0.0002832771,0.0002545885,0.0002774058,0.00002108762,0.000229686,0.0001808187,0.00001640591,0.00008193679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008702582,"threshold_uncertainty_score":0.4753325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554031502411147,"score_gpt":0.2783286826988239,"score_spread":0.2627883676747125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}