{"id":"W4300002445","doi":"10.1002/cmdc.202200399","title":"Effects of the 5′‐Triphosphate Metabolites of Ribavirin, Sofosbuvir, Vidarabine, and Molnupiravir on CTP Synthase Catalysis and Filament Formation: Implications for Repurposing Antiviral Agents against SARS‐CoV‐2","year":2022,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Research Nova Scotia; IWK Health Centre; Dalhousie University; Dalhousie Medical Research Foundation; QEII Foundation; Mitacs","keywords":"Biochemistry; Sofosbuvir; ATP synthase; Nucleotide; Chemistry; Enzyme; Nucleotide salvage; Allosteric regulation; Biology; Ribavirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221367,0.0002987974,0.0002035546,0.0001205638,0.00008235418,0.0001813429,0.0001726868,0.0003019169,0.001313203],"category_scores_gemma":[0.0001588419,0.0001244654,0.0002043344,0.0001087073,0.0001279146,0.0001675981,0.00008745286,0.000293036,0.0001919196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001296119,"about_ca_system_score_gemma":0.0001299076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006876693,"about_ca_topic_score_gemma":0.000492092,"domain_scores_codex":[0.9999001,0.00003647858,0.000009857088,0.00001458966,0.00001579493,0.00002307587],"domain_scores_gemma":[0.9999057,0.00003214689,0.00001761468,0.000008158777,0.00001080495,0.00002552947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001445618,0.0001356792,0.0003456904,0.00005035745,0.00001235187,0.0000665246,0.00001593819,0.0004522804,0.9941069,0.0000654519,0.00004258516,0.003260615],"study_design_scores_gemma":[0.00003028596,0.001163715,0.002359652,0.000003605494,0.00001132928,0.00006013995,0.00001417709,0.001460564,0.9943405,0.00002110199,0.0005292041,0.000005539816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965109,0.001695846,0.0005070462,0.0000415497,0.00002212246,0.00001550137,0.0002135421,0.00002341262,0.0009701116],"genre_scores_gemma":[0.9983556,0.0004464996,0.0005689545,0.00001897478,0.000005484878,0.000009162135,0.0001670542,0.000004451509,0.0004237591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313203,"threshold_uncertainty_score":0.004393101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554031502411147,"score_gpt":0.2783286826988239,"score_spread":0.2627883676747125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}