{"id":"W4300003008","doi":"10.1101/2022.09.29.510220","title":"Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Innate immune system; Heterologous; Immunology; Vaccination; Immune system; Biology; Pneumonia; Immunity; Streptococcus pneumoniae; Medicine; Microbiology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002398563,0.0007060271,0.0007369296,0.0007770846,0.0009344304,0.000195983,0.001314071,0.0008223882,0.0004181186],"category_scores_gemma":[0.0008598507,0.0006599078,0.0002868799,0.001025522,0.00009139137,0.0001756636,0.001052792,0.002729039,0.00006894249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006851408,"about_ca_system_score_gemma":0.0008063173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001867709,"about_ca_topic_score_gemma":0.00001114361,"domain_scores_codex":[0.9941856,0.002502228,0.001122921,0.001075252,0.0002163788,0.0008976456],"domain_scores_gemma":[0.9963679,0.0006326266,0.0008631345,0.001755436,0.0003385487,0.00004239018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006898941,0.0003309221,0.002397898,0.0002320837,0.0002363703,0.0002343622,0.0001713232,0.0004013577,0.9945793,0.0004939457,0.0001731035,0.00005940488],"study_design_scores_gemma":[0.002984312,0.0004532018,0.7186182,0.0005875726,0.0001977486,0.000003909224,0.0001496846,0.001321053,0.2610486,0.00001623832,0.01268542,0.001934106],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871249,0.007034812,0.0001728032,0.0007747256,0.001335437,0.00298762,0.0002073411,0.0003333916,0.00002894815],"genre_scores_gemma":[0.9974672,0.0002760508,0.0001848133,0.0001441677,0.00008960188,0.00160409,0.000009498553,0.0001301089,0.00009451145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7335308,"threshold_uncertainty_score":0.9995852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087314897646816,"score_gpt":0.2373199509224386,"score_spread":0.2264468019459704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}