{"id":"W4300089518","doi":"10.1002/psc.3455","title":"Synthesis of 5‐ and 7‐hydroxy indolizidin‐2‐one prostaglandin‐F<sub>2α</sub> modulators and activity on myometrial contractility towards development of agents for delaying preterm birth","year":2022,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Preterm Birth and Chorioamnionitis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Montréal","keywords":"Tocolytic agent; Prostaglandin; Chemistry; Contractility; Contraction (grammar); Uterine contraction; Dihedral angle; In utero; Pharmacology; Tocolytic; Endocrinology; Internal medicine; Medicine; Uterus; Preterm labor; Biochemistry; Pregnancy; Biology; Gestation; Fetus; Organic chemistry; Hydrogen bond","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054488,0.0002638874,0.0001655563,0.0001269665,0.00009156819,0.0001300853,0.000283086,0.000193923,0.001203518],"category_scores_gemma":[0.0001039587,0.0001006226,0.0001664319,0.0001324355,0.00009414832,0.0001677114,0.00011234,0.0003059332,0.0003766513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290766,"about_ca_system_score_gemma":0.0002728054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001841234,"about_ca_topic_score_gemma":0.0003466253,"domain_scores_codex":[0.9999489,0.00001152993,0.000005135631,0.000007395521,0.00001112588,0.00001594802],"domain_scores_gemma":[0.9999439,0.00000523478,0.00001710774,0.000006248438,0.000009718048,0.00001766317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003453834,0.00008650323,0.0001757452,0.0001344409,0.00001125658,0.0002479391,0.00003364389,0.0007368558,0.9899399,0.0004404702,0.00008419492,0.007763734],"study_design_scores_gemma":[0.0001276744,0.001831608,0.00149977,0.00001798849,0.00003476631,0.0003297476,0.00002618404,0.0009273757,0.9857095,0.0001415222,0.009336702,0.00001705083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818438,0.003944293,0.007131544,0.00014021,0.00007447081,0.000202428,0.0004686428,0.00005585196,0.006138806],"genre_scores_gemma":[0.9837896,0.002767424,0.00938618,0.00008284685,0.0000226476,0.0001023796,0.0005381519,0.00001185045,0.003298844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203518,"threshold_uncertainty_score":0.004026115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726348083254417,"score_gpt":0.2934930473033174,"score_spread":0.2562295664707733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}