{"id":"W4300117908","doi":"10.17615/zear-h193","title":"High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute; Canadian Institute for Advanced Research; Howard Hughes Medical Institute","keywords":"Nucleosome; Occupancy; Computational biology; Genetics; Biology; Histone; Computer science; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002543836,0.0001498415,0.0001348032,0.0000178963,0.0001165399,0.00004679945,0.0002031802,0.0001101784,0.0002664005],"category_scores_gemma":[0.00002222372,0.0001444515,0.00006960936,0.00007271121,0.0001036582,0.00000994902,0.0001939926,0.00005968004,0.00003462632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005419811,"about_ca_system_score_gemma":0.00003678424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008698742,"about_ca_topic_score_gemma":0.000004484659,"domain_scores_codex":[0.9992127,0.00001478784,0.0001572637,0.0003090294,0.0001103445,0.0001959025],"domain_scores_gemma":[0.9995691,0.000005708575,0.0000369999,0.0002527148,0.00001765906,0.0001178434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003526319,0.00001079247,0.004427286,0.00004455922,0.00004975474,0.000006146004,0.0005466953,0.0001006576,0.9520848,0.01249694,0.02997632,0.0002208287],"study_design_scores_gemma":[0.0002537902,0.0001449343,0.002760562,0.000007655716,0.00001194493,0.000003131179,0.0000755183,0.00002951091,0.9469292,0.002287562,0.04727831,0.0002178708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942303,0.001941903,0.0008756954,0.001199541,0.0001419189,0.00008978051,0.00003342874,0.00007028739,0.001417131],"genre_scores_gemma":[0.9924525,0.00002172648,0.003962793,0.001659803,0.0004565033,0.000006819032,0.00009693152,0.00002611216,0.001316827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.017302,"threshold_uncertainty_score":0.5890561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133320016040157,"score_gpt":0.2554093160489223,"score_spread":0.2420773144449066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}