{"id":"W4300305966","doi":"10.17615/b1wk-hz56","title":"Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston; National Heart, Lung, and Blood Institute; University of Texas MD Anderson Cancer Center; Centers for Disease Control and Prevention; Canadian Cancer Society Research Institute; National Institutes of Health; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; University of Texas Health Science Center at Houston; U.S. Department of Defense; Broad Institute; Johns Hopkins University; Duncan Family Institute for Cancer Prevention and Risk Assessment; Division of Cancer Prevention, National Cancer Institute; Virginia Department of Health; University of Southern California; Deutsche Forschungsgemeinschaft; State of Connecticut Department of Public Health; Ministerio de Economía y Competitividad; University of Hawai'i","keywords":"Locus (genetics); Colorectal cancer; Ethnic group; Genetics; Genome-wide association study; Biology; Gene; Single-nucleotide polymorphism; Cancer; Genotype; Anthropology; Sociology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001788965,0.0001936112,0.0005374416,0.00009491766,0.00003504147,0.00003200427,0.0001717896,0.0001467077,0.001002235],"category_scores_gemma":[0.0007099144,0.0001815467,0.00009395824,0.0006893059,0.0000855563,0.0002213244,0.0000615089,0.0002916072,0.000007340777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002748776,"about_ca_system_score_gemma":0.0006515095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002293224,"about_ca_topic_score_gemma":0.008777653,"domain_scores_codex":[0.9981751,0.0001243436,0.0005140039,0.0003998576,0.0005024017,0.0002843306],"domain_scores_gemma":[0.999016,0.0003582159,0.0001705555,0.0001914572,0.00009388498,0.0001698856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001085693,0.0003042862,0.9320288,0.0001870323,0.0001566271,0.00001210519,0.04069689,0.0001464404,0.02310028,0.00002143762,0.001490498,0.000769871],"study_design_scores_gemma":[0.003061488,0.001584506,0.9591064,0.00004448425,0.0001503577,3.74001e-7,0.005182232,0.0000432727,0.02867628,0.001419559,0.0005340526,0.0001970275],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921897,0.001698152,0.00004378648,0.004148659,0.0002654462,0.001061545,0.00002262792,0.00007942966,0.0004906668],"genre_scores_gemma":[0.9980562,0.00002587499,0.000353022,0.0005861631,0.0001540271,0.00005304759,0.00001293845,0.00002873065,0.0007299399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03551466,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03929275139169616,"score_gpt":0.2831445451337246,"score_spread":0.2438517937420284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}