{"id":"W4300427368","doi":"10.1002/acn3.51669","title":"Herpes simplex virus and rates of cognitive decline or whole brain atrophy in the Dominantly Inherited Alzheimer Network","year":2022,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research and Development; UCLH Biomedical Research Centre; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; National Institutes of Health; Neuroscience Research Australia; Genentech; Dementias Platform UK; Fleni; Alzheimer's Association; Alnylam Pharmaceuticals; FONDATION ALZHEIMER; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Wellcome Trust; University College London; Korea Health Industry Development Institute; National Institute on Aging; National Institute for Health and Care Research; Fondation Brain Canada; Demensförbundet; Japan Agency for Medical Research and Development; Bristol-Myers Squibb; Eli Lilly and Company; University College London Hospitals Biomedical Research Centre; Biogen; UK Dementia Research Institute; Medical Research Council; Cure Alzheimer's Fund","keywords":"Medicine; Cognitive decline; Atrophy; Herpes simplex virus; Asymptomatic; Cohort; Internal medicine; Cognition; Dementia; Immunology; Psychiatry; Disease; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009730083,0.0003465305,0.0003317802,0.0006754659,0.000216499,0.0004088209,0.0004026121,0.000308413,0.000894987],"category_scores_gemma":[0.002980908,0.0001863768,0.0004785098,0.0004562859,0.0001722242,0.0003972723,0.000401147,0.0003498618,0.0001221226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558087,"about_ca_system_score_gemma":0.0002628566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01211421,"about_ca_topic_score_gemma":0.0124664,"domain_scores_codex":[0.999707,0.00006561717,0.00002783163,0.0001011761,0.00005354634,0.00004469559],"domain_scores_gemma":[0.9984986,0.0002266908,0.0008600615,0.0001041292,0.0001381229,0.0001724395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002381255,0.00001694365,0.998833,0.000006921758,0.0000988596,0.00002844019,0.00002156988,0.00004241587,0.00008609516,0.000006206601,0.00004010037,0.0005813206],"study_design_scores_gemma":[0.000004864021,0.00005781378,0.9995017,0.000003651616,0.00003303348,0.0001185494,0.0000254546,0.0001660274,0.00003823875,0.00001289974,0.00003613119,0.000001650499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990407,0.0002882431,0.00003448705,0.00001219326,0.000003216964,0.000003677878,0.0003965648,0.000002461597,0.0002184895],"genre_scores_gemma":[0.9994136,0.00008587813,0.00005138498,0.000005871582,0.000005149278,0.000003379408,0.0003180815,9.121196e-7,0.0001157592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01211421,"threshold_uncertainty_score":0.02408737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1837361113977967,"score_gpt":0.4551654423270039,"score_spread":0.2714293309292072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}