{"id":"W4300505145","doi":"10.17615/a3jq-c466","title":"A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Hartwell Foundation; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; National Center for Advancing Translational Sciences; Wellcome Trust; GlaxoSmithKline; Novartis Pharma; Georgia Clinical and Translational Science Alliance; Pfizer","keywords":"Listeria monocytogenes; Imidazopyridine; Kinase; Antimicrobial; Biology; Microbiology; Pharmacology; Biochemistry; Genetics; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378205,0.0006123541,0.0005787075,0.0004419831,0.0001767955,0.000287946,0.000308964,0.0003513925,0.0009800078],"category_scores_gemma":[0.0001465091,0.0002095164,0.0004618189,0.0003512196,0.0001157112,0.000160177,0.0001788391,0.0003977142,0.0003768767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331701,"about_ca_system_score_gemma":0.0002520536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665146,"about_ca_topic_score_gemma":0.002075738,"domain_scores_codex":[0.9998509,0.00001885693,0.00001615893,0.00003153256,0.00005325117,0.000029188],"domain_scores_gemma":[0.9999188,0.00002116163,0.00002039545,0.000007025742,0.00001612118,0.00001652219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001978793,0.0001402743,0.0003071825,0.0001143869,0.00002234874,0.0001465621,0.0000149781,0.0002863862,0.9924381,0.00005085766,0.0001109122,0.006169956],"study_design_scores_gemma":[0.0002284401,0.004073065,0.007943934,0.00003152211,0.0001664864,0.001109741,0.00003534958,0.002001582,0.9798571,0.00004835098,0.004483005,0.00002143253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778199,0.00820418,0.005199678,0.0002796331,0.00007197809,0.0003619507,0.002044405,0.0003391463,0.005679323],"genre_scores_gemma":[0.9775717,0.006589468,0.008816299,0.0001980971,0.00002427684,0.0001453023,0.003062322,0.00003997177,0.003552743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009800078,"threshold_uncertainty_score":0.003278494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044546534207274,"score_gpt":0.2402942637738937,"score_spread":0.219848798431821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}