{"id":"W4300658419","doi":"10.17615/tchk-ac83","title":"Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease","year":2020,"lang":"en","type":"article","venue":"Figshare","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Hjärt-Lungfonden; British Heart Foundation; Fondation Leducq; University of North Carolina at Chapel Hill; Broad Institute; University of Texas Health Science Center at Houston; Donovan Family Foundation; Regione Emilia-Romagna; University of Wisconsin-Milwaukee; Canadian Institutes of Health Research; University of Washington; Massachusetts General Hospital; Russell and Diana Hawkins Family Foundation; U.S. Department of Agriculture","keywords":"Internal medicine; Cardiology; Mutation; Loss function; Coronary disease; Medicine; Function (biology); Coronary heart disease; Genetics; Biology; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005948023,0.0001276042,0.0001670168,0.00006241384,0.00006272152,0.000008739306,0.0001165137,0.00009723815,0.06230542],"category_scores_gemma":[0.000317835,0.0001334695,0.0000492873,0.0002163849,0.00002903977,0.00008805285,0.00008472853,0.0002962789,0.0003026923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001051916,"about_ca_system_score_gemma":0.00008943734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002138938,"about_ca_topic_score_gemma":0.000001739492,"domain_scores_codex":[0.9991371,0.0001256146,0.0002364426,0.0002220484,0.00009111904,0.0001876813],"domain_scores_gemma":[0.9992646,0.0001765786,0.00008455874,0.0000758867,0.00005412041,0.0003442288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008608345,0.001804078,0.145054,0.003245141,0.0006524319,0.001417422,0.005449312,0.01423385,0.04927025,0.001657277,0.5096089,0.258999],"study_design_scores_gemma":[0.003755545,0.0001099275,0.1701965,0.0001181429,0.0001772451,0.000008626625,0.00006756096,0.01531489,0.006504628,0.0007432467,0.8026448,0.0003588923],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7480631,0.01434618,0.00001138956,0.002672282,0.0005248646,0.001078178,0.2298631,0.0001320542,0.003308855],"genre_scores_gemma":[0.9855974,0.0001269813,0.00002576632,0.002542465,0.0001510228,0.0001018232,0.01138769,0.00001590057,0.00005099509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2930359,"threshold_uncertainty_score":0.9385518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1731985691376916,"score_gpt":0.4108128009637603,"score_spread":0.2376142318260687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}