{"id":"W4300688307","doi":"10.1097/tp.0000000000004324","title":"Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study","year":2022,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Natera","keywords":"Medicine; Biopsy; Cell-free fetal DNA; Antibody; Area under the curve; Internal medicine; Transplantation; Donor specific antibodies; Pathology; Kidney transplantation; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003939828,0.0003634621,0.0004738626,0.0001856303,0.0007905391,0.00007413742,0.0002822632,0.00008370059,0.0002586947],"category_scores_gemma":[0.00003336485,0.00027429,0.0001868329,0.0006435414,0.00005618886,0.000220079,0.00002423813,0.0004323968,0.00006356189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457451,"about_ca_system_score_gemma":0.0001040246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002559409,"about_ca_topic_score_gemma":0.000350878,"domain_scores_codex":[0.9969057,0.000480896,0.0007306252,0.0006949406,0.0008110412,0.0003767841],"domain_scores_gemma":[0.9980639,0.0006984701,0.0002894268,0.0007169454,0.00009667361,0.000134647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02767031,0.002633235,0.366189,0.0002100831,0.0006353101,0.0009596804,0.01314426,0.0007225444,0.5868212,0.00001771954,0.0002037477,0.0007929104],"study_design_scores_gemma":[0.04968689,0.002436422,0.9075862,0.000248151,0.001588944,0.0002173142,0.003899761,0.0003247121,0.03271334,0.00005834681,0.0007513356,0.0004886081],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991023,0.000423782,0.002300399,0.0003866052,0.0004924525,0.002075807,0.00196973,0.0002456126,0.001082613],"genre_scores_gemma":[0.9835095,0.002187123,0.0004162015,0.0002011826,0.000152416,0.0001617691,0.01297785,0.00005979372,0.0003341743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5541078,"threshold_uncertainty_score":0.9999709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02273203868309551,"score_gpt":0.2856248778181515,"score_spread":0.262892839135056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}