{"id":"W4300688307","doi":"10.1097/tp.0000000000004324","title":"Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study","year":2022,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Natera","keywords":"Medicine; Biopsy; Cell-free fetal DNA; Antibody; Area under the curve; Internal medicine; Transplantation; Donor specific antibodies; Pathology; Kidney transplantation; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008118881,0.000528625,0.0007710342,0.0003607487,0.0002230009,0.0007160645,0.0004549825,0.0006456209,0.001345325],"category_scores_gemma":[0.004315987,0.0001878649,0.001064572,0.0003252091,0.0002767185,0.0005219146,0.0003713523,0.0006546414,0.0004096862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583693,"about_ca_system_score_gemma":0.000346165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004178486,"about_ca_topic_score_gemma":0.000665485,"domain_scores_codex":[0.9966017,0.002156628,0.0002763795,0.0003494164,0.0004172092,0.0001986693],"domain_scores_gemma":[0.9935407,0.002318722,0.001674484,0.0008077238,0.0006627581,0.0009956134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2349772,0.004450853,0.6640499,0.001391681,0.00613433,0.000684707,0.0005832667,0.0005998174,0.008244207,0.0003825171,0.0057653,0.07273627],"study_design_scores_gemma":[0.02445859,0.06575407,0.8903058,0.0002458048,0.005575645,0.003361429,0.0003808405,0.001224126,0.0017111,0.0002240714,0.006675704,0.00008284343],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931288,0.003064025,0.0004975313,0.0002116766,0.00002914293,0.000142168,0.001198226,0.00001753006,0.001710961],"genre_scores_gemma":[0.9962378,0.0004143617,0.0003211866,0.0002746459,0.00007087995,0.00007109252,0.002371591,0.000009822745,0.0002285666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008118881,"threshold_uncertainty_score":0.04293728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02273203868309551,"score_gpt":0.2856248778181515,"score_spread":0.262892839135056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}