{"id":"W4300688782","doi":"10.1371/journal.ppat.1010640","title":"Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Armand-Frappier Foundation; Natural Sciences and Engineering Research Council of Canada; McMaster University; Canada Research Chairs; McGill University","keywords":"Cell biology; Leishmania; Cleavage (geology); Metalloproteinase; Cell culture; Chemistry; Cell; Microbiology; Virulence; Biology; Matrix metalloproteinase; Biochemistry; Parasite hosting; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007166757,0.0002595212,0.0007290508,0.0002890042,0.0003703438,0.00002289816,0.0002667537,0.00005499736,0.001074109],"category_scores_gemma":[0.0006038952,0.0002503209,0.0002321152,0.0007065101,0.0000918947,0.0000757111,0.0004181075,0.0005491751,0.00006981364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249257,"about_ca_system_score_gemma":0.0001621892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003611594,"about_ca_topic_score_gemma":0.000005811216,"domain_scores_codex":[0.9969214,0.0002662986,0.0006078052,0.0005109116,0.001017481,0.0006761664],"domain_scores_gemma":[0.9983944,0.0002842455,0.0002842476,0.0006019584,0.0002315926,0.0002035669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001669507,0.0005928062,0.1967267,0.0006527439,0.0002091625,0.0006380458,0.001014766,0.000009102599,0.7978164,0.000156609,0.001842996,0.0001737296],"study_design_scores_gemma":[0.002941696,0.002273895,0.568565,0.0004454794,0.0005715636,0.0002069176,0.005889462,0.0005475578,0.4133373,0.0003136213,0.004147478,0.0007600738],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827158,0.00332257,0.00000679517,0.002521964,0.00007068418,0.0008225801,0.0002471285,0.0001172993,0.01017511],"genre_scores_gemma":[0.9964524,0.0004558328,0.0009000966,0.0002518955,0.0002623451,0.0001272615,0.00007311576,0.00006978864,0.001407272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3844791,"threshold_uncertainty_score":0.9999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03404730731987462,"score_gpt":0.2707140014716155,"score_spread":0.2366666941517409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}