{"id":"W4300688782","doi":"10.1371/journal.ppat.1010640","title":"Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Armand-Frappier Foundation; Natural Sciences and Engineering Research Council of Canada; McMaster University; Canada Research Chairs; McGill University","keywords":"Cell biology; Leishmania; Cleavage (geology); Metalloproteinase; Cell culture; Chemistry; Cell; Microbiology; Virulence; Biology; Matrix metalloproteinase; Biochemistry; Parasite hosting; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740184,0.0002910283,0.0002294408,0.0001906682,0.0001347429,0.0004458306,0.0001664876,0.0003109723,0.0006263775],"category_scores_gemma":[0.0001441538,0.0001512538,0.000245808,0.0001391056,0.0001791086,0.00032752,0.0001881107,0.0004946403,0.0004306057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029297,"about_ca_system_score_gemma":0.0001142282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002017769,"about_ca_topic_score_gemma":0.0003958281,"domain_scores_codex":[0.9998671,0.00002093633,0.00001392106,0.00002548288,0.00004721132,0.00002539213],"domain_scores_gemma":[0.9999275,0.00001406781,0.00002286913,0.000009792016,0.00001443011,0.00001132458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005446402,0.000006368123,0.0001975648,0.00004141918,0.000002408994,0.00009754636,0.00001178872,0.00002400519,0.9987753,0.00004256554,0.00001248466,0.0007341828],"study_design_scores_gemma":[0.000005814848,0.0001856824,0.006803366,0.00001230207,0.00001329563,0.0009799642,0.00005428805,0.0005576033,0.988355,0.00006900697,0.002960233,0.000003442897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885821,0.006941226,0.002707804,0.0001699086,0.00001507105,0.00002037649,0.0002583661,0.00003626538,0.001268878],"genre_scores_gemma":[0.991104,0.004011956,0.002544965,0.00008921206,0.0000129712,0.00001650632,0.000730436,0.00001866614,0.001471176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006263775,"threshold_uncertainty_score":0.002095461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03404730731987462,"score_gpt":0.2707140014716155,"score_spread":0.2366666941517409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}