{"id":"W4300713440","doi":"10.1182/blood-2008-09-179630","title":"FAS-L, IL-10, and double-negative CD4−CD8− TCR α/β+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; E-Rare","keywords":"Autoimmune lymphoproliferative syndrome; Hypergammaglobulinemia; CD8; Fas receptor; Immunology; Apoptosis; Lymphoproliferative disorders; Autoimmunity; T cell; Biology; Cytotoxic T cell; Molecular biology; In vitro; Antigen; Immune system; Programmed cell death; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551657,0.0002686771,0.0005558242,0.0001805849,0.0001719602,0.00001563191,0.0001107779,0.0003227107,0.0007699507],"category_scores_gemma":[0.00006262713,0.0002280208,0.00009946107,0.0003006706,0.0002421936,0.0002617493,0.00003413873,0.0002777535,0.0000683344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000583841,"about_ca_system_score_gemma":0.00007830048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308085,"about_ca_topic_score_gemma":0.00001299506,"domain_scores_codex":[0.9986008,0.0001650808,0.0004989443,0.0003476257,0.00008357982,0.0003039328],"domain_scores_gemma":[0.9985554,0.0001209294,0.0006588781,0.000269574,0.0003714151,0.00002382499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009560356,0.002217158,0.005249731,0.00006990066,0.002440718,0.00002097885,0.0009874029,0.00006140998,0.9746219,0.0002213447,0.004139184,0.0004099225],"study_design_scores_gemma":[0.01485852,0.005485575,0.0960747,0.0004455845,0.0006127267,0.0002063996,0.001495418,0.00001661936,0.878764,0.00007566889,0.00158019,0.0003845809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939795,0.0007561051,0.00006947179,0.00009380189,0.0006324139,0.0004570719,0.00003547329,0.00007591301,0.003900271],"genre_scores_gemma":[0.9819793,0.0001026979,0.00003444186,0.00008331345,0.000008774163,0.00001870511,0.0001336686,0.00001959857,0.01761955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09585787,"threshold_uncertainty_score":0.9298418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007031756609719515,"score_gpt":0.1961244545434413,"score_spread":0.1890926979337218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}