{"id":"W4300713440","doi":"10.1182/blood-2008-09-179630","title":"FAS-L, IL-10, and double-negative CD4−CD8− TCR α/β+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; E-Rare","keywords":"Autoimmune lymphoproliferative syndrome; Hypergammaglobulinemia; CD8; Fas receptor; Immunology; Apoptosis; Lymphoproliferative disorders; Autoimmunity; T cell; Biology; Cytotoxic T cell; Molecular biology; In vitro; Antigen; Immune system; Programmed cell death; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133075,0.000502403,0.0001662384,0.001050778,0.0001008665,0.0003858375,0.0001202604,0.0003415385,0.001582398],"category_scores_gemma":[0.0006100426,0.0001500749,0.00008455667,0.000224161,0.0002427193,0.000199114,0.000179859,0.0003169197,0.0003148237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001170271,"about_ca_system_score_gemma":0.00005590881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001422245,"about_ca_topic_score_gemma":0.0001828116,"domain_scores_codex":[0.9996632,0.00009570816,0.00004700803,0.00005613787,0.00009819577,0.00003979928],"domain_scores_gemma":[0.999689,0.00009259251,0.00009567988,0.00002784637,0.00004893906,0.00004593832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004601328,0.00006631498,0.04883399,0.00008143435,0.0000288054,0.0007864032,0.00008637233,0.00006589015,0.941633,0.0001267472,0.00008912811,0.007741782],"study_design_scores_gemma":[0.0001494991,0.001362678,0.2185904,0.00007402288,0.0001526275,0.02748984,0.0003937499,0.003599823,0.741172,0.0006055274,0.006388956,0.00002099294],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948355,0.001926956,0.001793757,0.00004296898,0.00001601312,0.0000136336,0.00009447429,0.00004334532,0.00123332],"genre_scores_gemma":[0.9978576,0.0002466696,0.001258049,0.00001781861,0.00001643497,0.00001070185,0.0001176246,0.000003237794,0.0004717325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001582398,"threshold_uncertainty_score":0.005293608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007031756609719515,"score_gpt":0.1961244545434413,"score_spread":0.1890926979337218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}