{"id":"W4300816588","doi":"10.1016/j.omtm.2022.09.016","title":"Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Leukemia and Lymphoma Society of Canada","keywords":"Cytotoxic T cell; Immunotherapy; T-cell receptor; T cell; Antigen; Blockade; CD8; Adoptive cell transfer; Biology; Cancer immunotherapy; Immunology; Streptamer; Ex vivo; Cancer research; Immune system; Receptor; In vivo; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003593701,0.0005033819,0.0004367824,0.0003595719,0.0001586126,0.0006002803,0.0003130187,0.0004411062,0.002644934],"category_scores_gemma":[0.0001886528,0.0001572102,0.0002774833,0.0001877913,0.0001455998,0.0003675116,0.0003180799,0.001296945,0.000776912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155836,"about_ca_system_score_gemma":0.0002573988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002708967,"about_ca_topic_score_gemma":0.0006259761,"domain_scores_codex":[0.9997444,0.00004986796,0.00002086751,0.0000393379,0.00007235471,0.00007323679],"domain_scores_gemma":[0.9999185,0.00001754522,0.00001432795,0.00001349076,0.000009390832,0.00002673442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003291859,0.0003491557,0.0002461603,0.00004070204,0.00001099852,0.00002304873,0.00001976727,0.000369457,0.9873498,0.0001430665,0.000373545,0.01074511],"study_design_scores_gemma":[0.000104493,0.001249797,0.001617782,0.000007282567,0.00004610188,0.0001521324,0.00001566977,0.002009762,0.9910165,0.0001017096,0.003670681,0.000008147732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706476,0.002118693,0.020805,0.0002813895,0.0001134573,0.0002286496,0.0006025254,0.0006263908,0.004576236],"genre_scores_gemma":[0.9855546,0.0007055302,0.01014583,0.0001238832,0.00004174143,0.0001539114,0.000483703,0.00005693234,0.002733893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002644934,"threshold_uncertainty_score":0.008848131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266808610469028,"score_gpt":0.4547419606321207,"score_spread":0.3280610995852179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}