{"id":"W4300816851","doi":"10.2337/db22-0121","title":"Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cell growth; Biology; Peroxiredoxin; Reactive oxygen species; Cell biology; Transcriptome; Cell; Glucose homeostasis; Biochemistry; Gene expression; Insulin; Gene; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002216166,0.0002525965,0.0002442193,0.0003604367,0.0002198496,0.0002996952,0.0001263707,0.0001720448,0.0006535545],"category_scores_gemma":[0.000141671,0.0001311701,0.0003595896,0.0002699158,0.0002205197,0.0001204014,0.0001561246,0.0003832295,0.0003191406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001474815,"about_ca_system_score_gemma":0.0001992783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004327428,"about_ca_topic_score_gemma":0.0008153209,"domain_scores_codex":[0.9998854,0.00001108956,0.000007857516,0.00004803174,0.00002656643,0.00002095687],"domain_scores_gemma":[0.9998662,0.00003092974,0.0000314551,0.00002217144,0.00002650491,0.00002272871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004594749,0.000005173689,0.0002318117,0.00001189214,0.000002889357,0.000007936807,0.000008580278,0.00002611501,0.9988087,0.00001544941,0.00001245299,0.0008230425],"study_design_scores_gemma":[0.00001396093,0.0002067969,0.04149271,0.000009302707,0.00003369938,0.0001054402,0.00005616872,0.001507526,0.9543331,0.0001685926,0.002063642,0.000009000607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780929,0.001314352,0.01672964,0.0001145118,0.00004435346,0.00003861394,0.002382574,0.0001966313,0.00108642],"genre_scores_gemma":[0.9608516,0.00209394,0.02559699,0.0002479022,0.00003373658,0.0002025539,0.007291503,0.0001271642,0.003554581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006535545,"threshold_uncertainty_score":0.002186418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03033586000605849,"score_gpt":0.2346752734899998,"score_spread":0.2043394134839412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}