{"id":"W4300817734","doi":"10.1016/j.scr.2022.102932","title":"Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"H2020 European Research Council; Fonds Wetenschappelijk Onderzoek","keywords":"Induced pluripotent stem cell; Biology; Peripheral blood mononuclear cell; Connective tissue; Sendai virus; Marfan syndrome; Reprogramming; Cell biology; Embryonic stem cell; Cell; Internal medicine; Genetics; Medicine; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007401116,0.00008560171,0.0001147511,0.0001728257,0.0002241053,0.00002820277,0.0001954922,0.00006232576,0.0002593556],"category_scores_gemma":[0.00004841007,0.00009202135,0.00002678736,0.0003003458,0.00008441671,0.000006913916,0.0004872018,0.0002164139,0.000009023573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003974,"about_ca_system_score_gemma":0.0001506681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002778796,"about_ca_topic_score_gemma":0.00006481096,"domain_scores_codex":[0.9978743,0.0006810069,0.0001729423,0.0004131776,0.0006048896,0.0002537452],"domain_scores_gemma":[0.9990845,0.00004728023,0.00004585092,0.0003771024,0.0003578961,0.00008730849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002197476,0.0001949125,0.0009979841,0.00002569705,0.00002360129,0.00001372276,0.0003964873,0.0003874256,0.9859409,0.00001632483,0.0004749139,0.01130834],"study_design_scores_gemma":[0.0005985732,0.004451778,0.001068141,0.000005181559,0.000005872975,0.000009810949,0.001646346,0.002890457,0.9818392,0.00009156781,0.007244224,0.0001487953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968117,0.001972575,0.00005464766,0.00007549203,0.00006322778,0.0004048485,0.00008096554,0.000005109879,0.0005314389],"genre_scores_gemma":[0.9978948,0.0001571731,0.00007781883,0.0000106678,0.00005104323,0.00006832328,0.000672925,0.00002197872,0.001045282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01115954,"threshold_uncertainty_score":0.3752522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0885182811617526,"score_gpt":0.3570795352242156,"score_spread":0.2685612540624631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}