{"id":"W4300817734","doi":"10.1016/j.scr.2022.102932","title":"Generation and validation of an iPSC line (BBANTWi008-A) from a Loeys-Dietz Syndrome type 3 patient","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"H2020 European Research Council; Fonds Wetenschappelijk Onderzoek","keywords":"Induced pluripotent stem cell; Biology; Peripheral blood mononuclear cell; Connective tissue; Sendai virus; Marfan syndrome; Reprogramming; Cell biology; Embryonic stem cell; Cell; Internal medicine; Genetics; Medicine; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059872,0.0003650946,0.0003730157,0.0008917804,0.0006754353,0.0004662388,0.0004083881,0.0008335555,0.003213709],"category_scores_gemma":[0.0007982396,0.0001747765,0.000611019,0.0004084467,0.0003552474,0.0001569752,0.0004328874,0.0009064172,0.002041806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777484,"about_ca_system_score_gemma":0.000336006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008176573,"about_ca_topic_score_gemma":0.0007179364,"domain_scores_codex":[0.9994829,0.00007710848,0.0001057835,0.0001051354,0.0001736386,0.00005546801],"domain_scores_gemma":[0.9995041,0.0001404007,0.00003049576,0.0001226351,0.0001091287,0.00009318835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001418467,0.0001712705,0.001725664,0.00005189731,0.00002426026,0.002303266,0.0002515822,0.0002784158,0.9898834,0.0004938586,0.0002735638,0.004401046],"study_design_scores_gemma":[0.0001838203,0.001188385,0.02491346,0.00007447034,0.000190067,0.02217011,0.0002963335,0.004155376,0.9228421,0.0004164808,0.02353012,0.00003922631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562371,0.000810766,0.02990081,0.0002595366,0.0001556584,0.0008806752,0.00552414,0.0002265841,0.006004614],"genre_scores_gemma":[0.9267683,0.001362881,0.04454626,0.00039607,0.00006933016,0.00105775,0.01908996,0.0002406019,0.006468765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003213709,"threshold_uncertainty_score":0.01075089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0885182811617526,"score_gpt":0.3570795352242156,"score_spread":0.2685612540624631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}