{"id":"W4300818819","doi":"10.1016/j.ab.2022.114934","title":"Application of a HyPer-3 sensor to monitor intracellular H2O2 generation induced by phenolic acids in differentiated Caco-2 cells","year":2022,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Intracellular; Extracellular; Antioxidant; Hydrogen peroxide; Caco-2; Flow cytometry; Chemistry; Biochemistry; Cell biology; Aquaporin; Confocal microscopy; Intestinal epithelium; Biology; Cell; Epithelium; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355768,0.0003646909,0.0003040446,0.0001757184,0.000200138,0.000296864,0.0003065823,0.0006234629,0.0007050709],"category_scores_gemma":[0.0001262902,0.0002002003,0.0003589569,0.0002525185,0.0003238157,0.000330803,0.0002513389,0.0008557698,0.000201907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004357186,"about_ca_system_score_gemma":0.0002890713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000907238,"about_ca_topic_score_gemma":0.001238363,"domain_scores_codex":[0.9997857,0.00003382907,0.0000131276,0.00005451828,0.00006222331,0.00005058951],"domain_scores_gemma":[0.9998701,0.00002688897,0.00003130502,0.00001171803,0.00003070831,0.00002920727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004136857,0.000005181564,0.00004689327,0.00001168334,0.000001687389,0.00001089129,0.000006986821,0.00001046306,0.9996977,0.00001720748,0.000007441554,0.0001425126],"study_design_scores_gemma":[0.000005051116,0.00004931626,0.0009502518,0.000001501492,0.000005378156,0.00003091034,0.00002220358,0.0004782985,0.9981065,0.00001483151,0.0003329605,0.000002982021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660379,0.001042401,0.03012375,0.0003940985,0.0001003838,0.00005115959,0.0007025538,0.0002165927,0.001330974],"genre_scores_gemma":[0.9687675,0.0006440565,0.02696215,0.0002369028,0.00002229901,0.00009194095,0.0007035217,0.00003168114,0.00254004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000907238,"threshold_uncertainty_score":0.00316143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008442483403696254,"score_gpt":0.2283780609260946,"score_spread":0.2199355775223984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}