{"id":"W4300854205","doi":"10.17615/k3vg-tb84","title":"Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Australian Research Council; Medical Research Council; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; National Institutes of Health; Institute of Genetics; Universität Greifswald; H. Lundbeck A/S; Chinese Society of Clinical Oncology; Rheinische Friedrich-Wilhelms-Universität Bonn; Göteborgs Universitet; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Bundesministerium für Bildung und Forschung; Háskóli Íslands; Landspítali Háskólasjúkrahús; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Queensland University of Technology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; University of New England; Massachusetts Institute of Technology; European Science Foundation; Institut for Klinisk Medicin, Aarhus Universitet; Scottish Funding Council; European Commission; University of Aberdeen; National Science Foundation; Massachusetts General Hospital; Universidad del Atlántico; Aarhus Universitet; Scottish Government; QIMR Berghofer Medical Research Institute; Wellcome Trust; King's College London; Vetenskapsrådet; Virginia Commonwealth University; Centro de Investigación Biomédica en Red de Salud Mental; Aarhus Universitetshospital; Universidad de Granada; ZonMw; National Alliance for Research on Schizophrenia and Depression; Menzies Centre for Australian Studies, King's College London, University of London; Florida Atlantic University; Ministry of Cultural Affairs; Philipps-Universität Marburg; Cardiff University; University of Texas Southwestern Medical Center; Centre for Cognitive Ageing and Cognitive Epidemiology; University of Pittsburgh; National Institute for Health and Care Research; Broad Institute; Centre Hospitalier Universitaire Vaudois; GlaxoSmithKline; National Cancer Institute; Lundbeckfonden; Kaiser Permanente; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Dundee","keywords":"Depression (economics); Genomics; Association (psychology); Genome-wide association study; Major depressive disorder; Psychiatric genetics; Psychiatry; Genetic association; Psychology; Medicine; Genome; Genetics; Biology; Genotype; Gene; Schizophrenia (object-oriented programming); Single-nucleotide polymorphism; Psychotherapist; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003095004,0.0005895105,0.0006928421,0.0008880303,0.0004892099,0.0007069457,0.0005930524,0.0005653357,0.001879427],"category_scores_gemma":[0.003121772,0.0002266839,0.001058057,0.001591675,0.0002385294,0.0001801463,0.0007822906,0.0007010595,0.0001708343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690979,"about_ca_system_score_gemma":0.0003986233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006954691,"about_ca_topic_score_gemma":0.008795178,"domain_scores_codex":[0.9982778,0.0008064667,0.0001161923,0.0005283626,0.0001515982,0.000119599],"domain_scores_gemma":[0.9986044,0.0004195939,0.0003646603,0.0003011902,0.0001544824,0.0001557025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009952269,0.00006379644,0.9766039,0.00009039811,0.004083508,0.0002331592,0.00009828891,0.0004961691,0.005708103,0.0002121575,0.002046878,0.00936854],"study_design_scores_gemma":[0.000202431,0.0001081747,0.9949189,0.00002187527,0.00180408,0.0003045796,0.00004587386,0.001007782,0.0005046637,0.0003108387,0.000759032,0.00001167311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852042,0.002671884,0.004208314,0.0005462168,0.00006877819,0.0000862973,0.00630877,0.0000629221,0.0008425101],"genre_scores_gemma":[0.9924722,0.0005202002,0.002636957,0.0001312539,0.00005328805,0.00008269291,0.003726387,0.00002055909,0.0003565987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006954691,"threshold_uncertainty_score":0.01636815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915978114459552,"score_gpt":0.2573600856155372,"score_spread":0.2282003044709417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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