{"id":"W4300854205","doi":"10.17615/k3vg-tb84","title":"Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Australian Research Council; Medical Research Council; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; National Institutes of Health; Institute of Genetics; Universität Greifswald; H. Lundbeck A/S; Chinese Society of Clinical Oncology; Rheinische Friedrich-Wilhelms-Universität Bonn; Göteborgs Universitet; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Bundesministerium für Bildung und Forschung; Háskóli Íslands; Landspítali Háskólasjúkrahús; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Queensland University of Technology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Glasgow; University of New England; Massachusetts Institute of Technology; European Science Foundation; Institut for Klinisk Medicin, Aarhus Universitet; Scottish Funding Council; European Commission; University of Aberdeen; National Science Foundation; Massachusetts General Hospital; Universidad del Atlántico; Aarhus Universitet; Scottish Government; QIMR Berghofer Medical Research Institute; Wellcome Trust; King's College London; Vetenskapsrådet; Virginia Commonwealth University; Centro de Investigación Biomédica en Red de Salud Mental; Aarhus Universitetshospital; Universidad de Granada; ZonMw; National Alliance for Research on Schizophrenia and Depression; Menzies Centre for Australian Studies, King's College London, University of London; Florida Atlantic University; Ministry of Cultural Affairs; Philipps-Universität Marburg; Cardiff University; University of Texas Southwestern Medical Center; Centre for Cognitive Ageing and Cognitive Epidemiology; University of Pittsburgh; National Institute for Health and Care Research; Broad Institute; Centre Hospitalier Universitaire Vaudois; GlaxoSmithKline; National Cancer Institute; Lundbeckfonden; Kaiser Permanente; Vrije Universiteit Amsterdam; Stiftelsen för Strategisk Forskning; University of Dundee","keywords":"Depression (economics); Genomics; Association (psychology); Genome-wide association study; Major depressive disorder; Psychiatric genetics; Psychiatry; Genetic association; Psychology; Medicine; Genome; Genetics; Biology; Genotype; Gene; Schizophrenia (object-oriented programming); Single-nucleotide polymorphism; Psychotherapist; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369739,0.0001837549,0.0003474662,0.00003954397,0.0004585039,0.00006038043,0.0002028495,0.000184732,0.00007481701],"category_scores_gemma":[0.0003281462,0.0001361539,0.0001275162,0.0003062185,0.00009044104,0.0002083363,0.0001176952,0.0002078737,0.000008752377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308529,"about_ca_system_score_gemma":0.0003951174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000204294,"about_ca_topic_score_gemma":0.0000969364,"domain_scores_codex":[0.9984568,0.00007614635,0.0005329911,0.000348796,0.0002892555,0.000296011],"domain_scores_gemma":[0.9985675,0.0003747289,0.0005761124,0.0002985468,0.00007321717,0.0001098533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004864363,0.00009139584,0.9361919,0.0003918026,0.000137465,0.000001818657,0.003994339,0.000007513959,0.001077134,0.05033632,0.007029194,0.000254733],"study_design_scores_gemma":[0.00278677,0.000118169,0.8944345,0.00007604476,0.000242257,0.000002938645,0.0006182134,0.00004799648,0.005062727,0.07467879,0.0217049,0.000226688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9303588,0.006544448,0.0098026,0.04075855,0.0008712019,0.003432472,0.0001899054,0.0001959862,0.007846077],"genre_scores_gemma":[0.965436,0.001037365,0.02628935,0.005865258,0.0003755235,0.0001146605,0.0003836174,0.00004955502,0.0004486242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04175734,"threshold_uncertainty_score":0.5552196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915978114459552,"score_gpt":0.2573600856155372,"score_spread":0.2282003044709417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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