{"id":"W4300864490","doi":"10.1093/pnasnexus/pgac219","title":"Socioeconomic disadvantage, chronic stress, and proinflammatory phenotype: an integrative data analysis across the lifecourse","year":2022,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Proinflammatory cytokine; Disadvantage; Socioeconomic status; Chronic stress; Context (archaeology); Psychology; Medicine; Inflammation; Biology; Immunology; Population; Environmental health; Neuroscience; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320212,0.000179522,0.0002258728,0.00005523772,0.0009592088,0.0001833564,0.001084526,0.00002663292,0.0004929187],"category_scores_gemma":[0.0001229515,0.0001304618,0.00007153516,0.0002697039,0.0003257455,0.0004001429,0.001141186,0.0003428841,0.00002401373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139483,"about_ca_system_score_gemma":0.0001570187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001466518,"about_ca_topic_score_gemma":0.001497148,"domain_scores_codex":[0.9981088,0.0003732557,0.0002250635,0.0007135709,0.0002238027,0.0003555312],"domain_scores_gemma":[0.9982325,0.0003250373,0.0001688084,0.00116608,0.00001106161,0.00009647127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00280725,0.001893972,0.1759174,0.0002085401,0.001845968,0.0008738759,0.05127204,0.03074197,0.06494688,0.01783024,0.004893993,0.6467679],"study_design_scores_gemma":[0.004176287,0.002102551,0.3137232,0.00004776646,0.001906496,0.0001709778,0.06959377,0.4920059,0.02483757,0.004460713,0.0842465,0.002728242],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957748,0.001180213,0.000149118,0.0004565872,0.0002010997,0.0003236449,0.001560235,0.0000651853,0.0002890922],"genre_scores_gemma":[0.998349,0.0003611951,0.00001371141,0.0003214782,0.0001311153,0.0001036475,0.00008120578,0.00002193768,0.0006167138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6440396,"threshold_uncertainty_score":0.7377555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02765712074974023,"score_gpt":0.3336408528431546,"score_spread":0.3059837320934144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}