{"id":"W4300888799","doi":"10.1136/annrheumdis-2022-eular.1817","title":"POS0054 DYSFUNCTION OF REGULATORY B CELLS IN GIANT CELL ARTERITIS (GCA)","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"EMD Serono; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Innovative Medicines Initiative; Science for Life Laboratory; Argenx; Wellcome Trust","keywords":"Medicine; Immunology; Regulatory B cells; Proinflammatory cytokine; Peripheral blood mononuclear cell; Pathogenesis; Interleukin 10; Internal medicine; Inflammation; Cytokine; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003541817,0.0004684779,0.0002860089,0.0004679689,0.0003513183,0.0005608754,0.0004617782,0.0009194919,0.006786872],"category_scores_gemma":[0.0004486245,0.0001502804,0.0002361919,0.0002771872,0.0004836773,0.0002445707,0.0002638366,0.0006492185,0.001441156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971466,"about_ca_system_score_gemma":0.0004197889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241295,"about_ca_topic_score_gemma":0.0002168726,"domain_scores_codex":[0.9996943,0.00009003938,0.00003320749,0.00004574062,0.00006149699,0.00007511423],"domain_scores_gemma":[0.9997913,0.00003301643,0.00005258259,0.00002062393,0.00001985403,0.00008260372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006904311,0.0004197412,0.01071404,0.0002936799,0.00009866604,0.005301109,0.0000800001,0.0003722696,0.9462082,0.001887271,0.002800239,0.02492043],"study_design_scores_gemma":[0.003426885,0.01006081,0.2219525,0.0002639076,0.0005043237,0.04156466,0.0008563141,0.005146276,0.6524608,0.006911044,0.05675656,0.00009592096],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887432,0.002337635,0.0007470085,0.0005222433,0.0003161932,0.00002309892,0.0005568707,0.0001382377,0.006615488],"genre_scores_gemma":[0.996658,0.0003735366,0.0003522643,0.0002490543,0.00006010899,0.00002242207,0.0003986528,0.00002015034,0.001865768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006786872,"threshold_uncertainty_score":0.02270436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02820505978458229,"score_gpt":0.2814120897991808,"score_spread":0.2532070300145984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}