{"id":"W4300960975","doi":"10.3389/fimmu.2022.997240","title":"Dynamic changes in metabolites of the kynurenine pathway in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease: A systematic Review and meta-analysis","year":2022,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Student Research Committee, Tabriz University of Medical Sciences; Shahid Beheshti University of Medical Sciences","keywords":"Kynurenic acid; Kynurenine; Kynurenine pathway; Parkinson's disease; Medicine; Internal medicine; Quinolinic acid; Disease; Indoleamine 2,3-dioxygenase; Meta-analysis; Endocrinology; Nicotinamide adenine dinucleotide; Tryptophan; Pharmacology; Chemistry; Biochemistry; NAD+ kinase; Amino acid; Enzyme; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008159861,0.0006975653,0.006746148,0.00147627,0.00009709333,0.00003827026,0.001087494,0.0001414,0.0001403478],"category_scores_gemma":[0.002026363,0.0004345926,0.001187665,0.003158069,0.0005597891,0.0001137987,0.0006789947,0.0006608572,0.000001095944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187568,"about_ca_system_score_gemma":0.0002571745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003429683,"about_ca_topic_score_gemma":0.0002531481,"domain_scores_codex":[0.9927196,0.003758263,0.001406794,0.001180531,0.0003766357,0.0005581785],"domain_scores_gemma":[0.9969713,0.0005734214,0.001059905,0.001236975,0.00001701911,0.000141395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000158458,0.0007937316,0.002168566,0.9218339,0.0463842,0.0001775544,0.0004676938,0.00001547276,0.000006247134,0.0007944078,0.0002562893,0.02694349],"study_design_scores_gemma":[0.000873842,0.00005141419,0.007393792,0.02824593,0.7277587,0.000008591699,0.0002503913,0.0001556569,0.000003430197,0.0009625365,0.2327423,0.001553477],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006205415,0.9942728,0.000004078264,0.0008054414,0.0002343103,0.003771017,0.0008158942,0.00002282577,0.00001155888],"genre_scores_gemma":[0.001319061,0.9948955,0.00004717758,0.0004284249,0.000004048236,0.002967851,0.0000834412,0.00005567044,0.0001988149],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8935879,"threshold_uncertainty_score":0.9998106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04236227607707809,"score_gpt":0.2868121006324525,"score_spread":0.2444498245553745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}