{"id":"W4300963191","doi":"10.3389/fmolb.2022.1017336","title":"Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity","year":2022,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytotoxicity; Amyloid (mycology); Islet; Chemistry; Biophysics; Biochemistry; Insulin; In vitro; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387819,0.0003682523,0.0003809662,0.0001064301,0.0003812764,0.0004948619,0.0003267873,0.0003525934,0.001161729],"category_scores_gemma":[0.0002614661,0.0001651878,0.0003667866,0.0001005773,0.0003342314,0.0005652272,0.000322093,0.0004477798,0.0002409521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665361,"about_ca_system_score_gemma":0.0006979672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001846736,"about_ca_topic_score_gemma":0.001750252,"domain_scores_codex":[0.9999404,0.00001085805,0.000003000543,0.00001092046,0.00001689035,0.00001795823],"domain_scores_gemma":[0.9999248,0.00002426621,0.00001708533,0.000005141183,0.00001147863,0.0000173583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074845,0.0006200937,0.02146978,0.001209746,0.0002047715,0.00301217,0.0004564917,0.5773098,0.3459321,0.02469559,0.001668206,0.0223463],"study_design_scores_gemma":[0.0001553266,0.0007367466,0.009648064,0.00009963244,0.0001800692,0.0005241265,0.0003449488,0.9159597,0.05589591,0.01074736,0.005631768,0.00007629154],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907539,0.001292085,0.004416351,0.0001538225,0.00003965973,0.00002123894,0.00009883793,0.00005818189,0.00316581],"genre_scores_gemma":[0.9963818,0.00132522,0.001521131,0.00004710372,0.000009328018,0.00003261709,0.0001471421,0.00001942065,0.0005162341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846736,"threshold_uncertainty_score":0.003886342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007757004461754928,"score_gpt":0.2482906841127518,"score_spread":0.2405336796509969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}