{"id":"W4300981033","doi":"10.21203/rs.3.rs-2090249/v1","title":"Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Allergy and Infectious Diseases; Research Institute, Nationwide Children's Hospital; Nationwide Children's Hospital","keywords":"Staphylococcus aureus; Vaccination; Immunology; Immune system; Adjuvant; Immunity; Biology; Microbiology; Virology; Medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800244,0.0002381379,0.0002132408,0.0001280466,0.00006030887,0.0003106724,0.00009596752,0.0002794903,0.00159522],"category_scores_gemma":[0.0001327564,0.00008546264,0.0001633061,0.00007837187,0.0002018125,0.000154658,0.0001939326,0.0006337599,0.0005390851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207683,"about_ca_system_score_gemma":0.0001449356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583969,"about_ca_topic_score_gemma":0.0001584332,"domain_scores_codex":[0.999866,0.00002565288,0.00000867884,0.00002207847,0.00003556845,0.00004202446],"domain_scores_gemma":[0.999879,0.00003259371,0.00003690031,0.00001773261,0.00001006983,0.00002367282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004990583,0.00002221882,0.0002300481,0.000009555283,0.000001198569,0.00001831069,0.000004738349,0.00005221913,0.9988049,0.000107951,0.00002685661,0.0006721889],"study_design_scores_gemma":[0.000009314415,0.0003601536,0.003229363,0.000005208427,0.000003897399,0.00009639079,0.00001422581,0.001178877,0.9937284,0.0001006731,0.001271737,0.000001731213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921585,0.000830922,0.004543285,0.0001513367,0.00004085003,0.00002073933,0.0001677701,0.0001001651,0.001986396],"genre_scores_gemma":[0.9963627,0.0002456796,0.001459807,0.00004339746,0.00001072771,0.00001158096,0.0001124177,0.00001968885,0.00173401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159522,"threshold_uncertainty_score":0.005336583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04520229181174227,"score_gpt":0.3912723932244985,"score_spread":0.3460701014127562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}