{"id":"W4301185148","doi":"10.1681/asn.2022040454","title":"Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Medicine; Infliximab; Immunosuppression; Randomized controlled trial; Kidney transplantation; Internal medicine; Clinical endpoint; Daclizumab; Tacrolimus; Placebo; Acute tubular necrosis; Anti-thymocyte globulin; Panel reactive antibody; Gastroenterology; Adverse effect; Thymoglobulin; Alemtuzumab; Urology; Transplantation; Discontinuation; Kidney; Tumor necrosis factor alpha; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004077545,0.00104643,0.002291356,0.0001857967,0.0002730291,0.001495298,0.0006220989,0.001310767,0.003282111],"category_scores_gemma":[0.003289252,0.0002646044,0.002148591,0.0003704297,0.0009604573,0.0008616647,0.0002861712,0.002049754,0.0003615156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006272159,"about_ca_system_score_gemma":0.0009618688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006096271,"about_ca_topic_score_gemma":0.001055005,"domain_scores_codex":[0.99863,0.0008878182,0.0001241723,0.0001205895,0.0001219218,0.0001155525],"domain_scores_gemma":[0.9970299,0.001167365,0.0008823823,0.0002339353,0.0001383066,0.0005480004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9683242,0.001703264,0.004287877,0.001088547,0.002841323,0.0001355105,0.00005028353,0.000335319,0.002953086,0.0001763981,0.001109166,0.01699505],"study_design_scores_gemma":[0.886119,0.08582866,0.01735356,0.0002608236,0.005528934,0.0003009425,0.00005512163,0.0007002003,0.001335073,0.0002933372,0.002179703,0.00004454394],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789401,0.01617856,0.0004865092,0.001007137,0.0003671236,0.0005278145,0.0008400664,0.00004599598,0.001606588],"genre_scores_gemma":[0.9911373,0.004128909,0.0005499872,0.001136285,0.0003641585,0.000357539,0.001147563,0.00001344109,0.001164988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004077545,"threshold_uncertainty_score":0.02156436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700466848281862,"score_gpt":0.2823441504001544,"score_spread":0.2653394819173358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}