{"id":"W4301185148","doi":"10.1681/asn.2022040454","title":"Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial","year":2022,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Medicine; Infliximab; Immunosuppression; Randomized controlled trial; Kidney transplantation; Internal medicine; Clinical endpoint; Daclizumab; Tacrolimus; Placebo; Acute tubular necrosis; Anti-thymocyte globulin; Panel reactive antibody; Gastroenterology; Adverse effect; Thymoglobulin; Alemtuzumab; Urology; Transplantation; Discontinuation; Kidney; Tumor necrosis factor alpha; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005161762,0.0001161228,0.0004908125,0.00009652704,0.0001481918,0.000003549832,0.000162713,0.00007053711,0.00001994362],"category_scores_gemma":[0.000343497,0.00006894778,0.0004174661,0.0005378147,0.0008931539,0.00005461162,0.00008474476,0.0005942705,1.422923e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001335737,"about_ca_system_score_gemma":0.0004423131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003774497,"about_ca_topic_score_gemma":0.00005188642,"domain_scores_codex":[0.9981664,0.000530488,0.0006737245,0.0001282492,0.000340576,0.0001605578],"domain_scores_gemma":[0.9979691,0.0002479384,0.001368607,0.0002127635,0.00007544175,0.000126135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4238068,0.006411321,0.2167939,0.0001140241,0.002073676,0.00002840091,0.004997242,0.002054841,0.2755097,0.00002127687,0.06005151,0.008137356],"study_design_scores_gemma":[0.09929862,0.006193928,0.8777895,0.0002341972,0.001152038,0.0006551971,0.00109177,0.0001987459,0.002258,0.0001627735,0.01080721,0.0001580105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936707,0.0003203608,0.000005315245,0.005286746,0.0002813263,0.0003184936,0.00008790553,0.000005323589,0.00002380708],"genre_scores_gemma":[0.9942811,0.001674301,0.000060483,0.003761563,0.0001819225,0.000005991066,0.000004787726,0.00001030548,0.00001957641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6609956,"threshold_uncertainty_score":0.5705936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700466848281862,"score_gpt":0.2823441504001544,"score_spread":0.2653394819173358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}