{"id":"W4301283258","doi":"10.1136/annrheumdis-2022-eular.787","title":"OP0269 BIOMARKERS TO PREDICT RISK OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING TOFACITINIB OR TUMOUR NECROSIS FACTOR INHIBITORS","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Sanofi Genzyme; Horizon Therapeutics; Sanofi; European Commission; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Tofacitinib; Etanercept; Internal medicine; Adalimumab; Rheumatoid arthritis; Hazard ratio; Rheumatoid factor; Pulmonary embolism; Gastroenterology; Surgery; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006768777,0.0004825104,0.0005901282,0.001057682,0.0003229337,0.001264706,0.0002684941,0.0009135742,0.002477183],"category_scores_gemma":[0.00291927,0.0002206714,0.0006683328,0.0008889981,0.0002226092,0.0004272576,0.0003698841,0.0009876408,0.0006645196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003430597,"about_ca_system_score_gemma":0.0004237383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008601291,"about_ca_topic_score_gemma":0.0009827618,"domain_scores_codex":[0.9993511,0.0001612621,0.00008845689,0.00008605269,0.0001975981,0.0001154066],"domain_scores_gemma":[0.9984009,0.0004541259,0.0006116016,0.00006750377,0.0002472638,0.0002185498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002844297,0.0002509299,0.9643851,0.0001148196,0.0004628584,0.0005511124,0.00005976768,0.0003327361,0.003372449,0.0001916122,0.001506582,0.02592778],"study_design_scores_gemma":[0.000259138,0.001434523,0.9824914,0.0001264729,0.000646938,0.004063276,0.0002230669,0.003357548,0.00239597,0.0006433667,0.004316302,0.00004196038],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985421,0.007191365,0.0005279456,0.0005377184,0.0001969674,0.00002992767,0.0009537286,0.00004339796,0.005097851],"genre_scores_gemma":[0.9968603,0.0007680533,0.0003917811,0.0002892543,0.0001829229,0.00001535332,0.0007869978,0.000006138791,0.0006992852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477183,"threshold_uncertainty_score":0.008286953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197678037723394,"score_gpt":0.262929628155183,"score_spread":0.2431618243828436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}