{"id":"W4301361266","doi":"10.17615/vfjm-vw90","title":"Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Hospital for Sick Children","keywords":"NUMB; Cell biology; Receptor; Association (psychology); Kinase; Chemistry; Biology; Neuroscience; Biochemistry; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008073449,0.0002050378,0.000239851,0.000198855,0.0002366808,0.0004509548,0.0001643096,0.0002148509,0.000947651],"category_scores_gemma":[0.0001490602,0.0001482046,0.0001927451,0.0001778491,0.000263499,0.0003315494,0.0004829068,0.0002946536,0.0003134628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009324881,"about_ca_system_score_gemma":0.0002063019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009564378,"about_ca_topic_score_gemma":0.001581056,"domain_scores_codex":[0.9998767,0.00001651929,0.000006743643,0.0000289035,0.00003511058,0.00003590508],"domain_scores_gemma":[0.9999266,0.000007669403,0.00002310455,0.000006241856,0.000008113794,0.00002831985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006605332,0.000005245471,0.0002142517,0.00001869242,0.000002268662,0.00005724496,0.00001263505,0.00003217451,0.9991463,0.00007726467,0.00001363981,0.0003542157],"study_design_scores_gemma":[0.00003096145,0.00006728386,0.05163509,0.00001704286,0.0000142983,0.0004681603,0.0001669813,0.002913754,0.9421793,0.0001484439,0.002349701,0.00000894474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970907,0.001168395,0.0007861032,0.00007623792,0.000006113088,0.000009140357,0.000119897,0.00002159055,0.0007218293],"genre_scores_gemma":[0.997544,0.0006664352,0.0007428466,0.00003779928,0.000003575627,0.00002938389,0.0001746332,0.00001266993,0.0007886887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009564378,"threshold_uncertainty_score":0.006765664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005596737224400561,"score_gpt":0.1979740807946483,"score_spread":0.1923773435702477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}