{"id":"W4301372494","doi":"10.1101/2022.10.03.510743","title":"MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> induces Ethionamide Resistance in <i>Mycobacterium abscessus</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Center, University of California, Davis; University of California, Davis; University of California Berkeley; Northwestern University; York University; National Institutes of Health; National Science Foundation","keywords":"Mycobacterium abscessus; Ethionamide; Mycobacterium tuberculosis; Biology; Microbiology; TetR; Antibiotics; Transposon mutagenesis; Pathogen; Drug resistance; Mycobacterium; Virology; Mutant; Gene; Tuberculosis; Transposable element; Genetics; Bacteria; Medicine; Gene expression; Ethambutol; Rifampicin; Repressor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486321,0.000312979,0.0002941884,0.0002054958,0.0001253846,0.0003185722,0.0002296534,0.0002702065,0.001467211],"category_scores_gemma":[0.0001741492,0.0001423086,0.0004010882,0.0001141424,0.000259962,0.0001096364,0.0003201932,0.0008178767,0.0007897711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000343343,"about_ca_system_score_gemma":0.000169013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009559158,"about_ca_topic_score_gemma":0.001083369,"domain_scores_codex":[0.9997377,0.00003949743,0.00002333988,0.00006034668,0.00007470833,0.00006439997],"domain_scores_gemma":[0.9998133,0.00003986247,0.00006685263,0.00001932635,0.00002489933,0.00003583305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003513411,0.00001375179,0.0001118183,0.00001575323,0.0000015293,0.00002205129,0.000008122605,0.00001871601,0.9994718,0.00002178402,0.00002968364,0.0002497239],"study_design_scores_gemma":[0.00001112137,0.0001870103,0.0103702,0.0000106271,0.00001039227,0.0002349925,0.0000803652,0.001520114,0.9853372,0.00003357707,0.002194791,0.00000973493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911553,0.0006776229,0.004497227,0.0001924054,0.00005853266,0.00005031204,0.001618248,0.000236068,0.00151441],"genre_scores_gemma":[0.9919578,0.0001753497,0.002909457,0.0001347903,0.00001368182,0.00004465623,0.002150167,0.00009762435,0.002516435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467211,"threshold_uncertainty_score":0.004908264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981285130922392,"score_gpt":0.2534319707223058,"score_spread":0.2336191194130819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}