{"id":"W4301392523","doi":"10.1097/jcp.0000000000001608","title":"A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants","year":2022,"lang":"en","type":"review","venue":"Journal of Clinical Psychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Centre for Addiction and Mental Health","funders":"","keywords":"Psilocybin; Serotonergic; Clinical trial; Psychology; Distress; Lysergic acid diethylamide; Antidepressant; Expectancy theory; Major depressive disorder; Clinical psychology; Hallucinogen; Psychiatry; Adverse effect; Randomized controlled trial; Medicine; Psychotherapist; Pharmacology; Anxiety; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009176503,0.0006645417,0.005173481,0.000496553,0.0002085228,0.00001873956,0.001605784,0.0006233915,0.004092245],"category_scores_gemma":[0.009471159,0.0003941778,0.001926918,0.0007223135,0.001360316,0.0001044155,0.0003925746,0.003476848,0.00004319822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003624508,"about_ca_system_score_gemma":0.0004219838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001415445,"about_ca_topic_score_gemma":6.693842e-7,"domain_scores_codex":[0.9860479,0.004840554,0.006761927,0.0008178887,0.0009297669,0.0006019755],"domain_scores_gemma":[0.9214258,0.07190559,0.005141717,0.0007909308,0.0004053645,0.0003305682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01033496,0.003387267,0.0002068834,0.00357566,0.004886265,0.000188775,0.001099637,0.000006193421,0.00000969508,0.005417008,0.0468119,0.9240758],"study_design_scores_gemma":[0.004788363,0.002827216,0.0005921639,0.005610193,0.002635468,0.0003584448,0.0004934396,0.000004216107,0.000001399145,0.0006052613,0.9816833,0.0004005828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007855261,0.9635242,0.00002310948,0.003442918,0.01708854,0.0009133227,0.00005348126,0.00001386809,0.007085262],"genre_scores_gemma":[0.01715924,0.9801846,0.00008058165,0.0008724238,0.001425712,0.0000805861,0.000001954854,0.00008193978,0.0001129421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9348714,"threshold_uncertainty_score":0.999851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3782338736090994,"score_gpt":0.6170873225525341,"score_spread":0.2388534489434347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}