{"id":"W4301394708","doi":"10.1016/j.celrep.2022.111442","title":"MICAL1 activation by PAK1 mediates actin filament disassembly","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Medical Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK","keywords":"PAK1; GTPase; Cell biology; Phosphorylation; CDC42; Rab; Actin cytoskeleton; Actin; Biology; Cytoskeleton; GTPase-activating protein; Actin remodeling; Signal transduction; Chemistry; Biochemistry; G protein; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420069,0.00009791063,0.00007892162,0.00002292863,0.0001642666,0.00002036149,0.0000738231,0.00004785575,0.0004914074],"category_scores_gemma":[0.00004307496,0.0001026631,0.00007934616,0.00005736035,0.00000949335,0.000003550373,0.000153627,0.0001093891,0.000004969361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004051979,"about_ca_system_score_gemma":0.00004425573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002652455,"about_ca_topic_score_gemma":0.000002150589,"domain_scores_codex":[0.9991229,0.00003797913,0.0002099441,0.0003075842,0.0001677053,0.0001539106],"domain_scores_gemma":[0.999423,0.00001014518,0.0001700835,0.0003047173,0.00002969225,0.00006239221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001248004,0.0001335803,0.00009420628,0.0000035337,0.00001224822,0.00001309688,0.00002318002,0.00002721047,0.9120938,0.000006712202,0.08712962,0.0004503588],"study_design_scores_gemma":[0.00005400492,0.00008043607,0.00001806128,9.706235e-7,0.000005515938,0.00002954207,0.0001081937,0.00002779406,0.5800393,0.00003544402,0.4195255,0.00007522387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931346,0.0003031344,0.000961351,0.0002496153,0.0006112902,0.0001569871,0.00001498515,0.00001504132,0.004553058],"genre_scores_gemma":[0.9913637,0.00005227331,0.0000640734,0.0002466507,0.00009850012,0.00007914826,0.001015675,0.00001985896,0.007060141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3323959,"threshold_uncertainty_score":0.5380567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005614803307542617,"score_gpt":0.220962662831114,"score_spread":0.2153478595235714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}