{"id":"W4301394708","doi":"10.1016/j.celrep.2022.111442","title":"MICAL1 activation by PAK1 mediates actin filament disassembly","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Medical Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK","keywords":"PAK1; GTPase; Cell biology; Phosphorylation; CDC42; Rab; Actin cytoskeleton; Actin; Biology; Cytoskeleton; GTPase-activating protein; Actin remodeling; Signal transduction; Chemistry; Biochemistry; G protein; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006261752,0.0002817484,0.0001168379,0.0001397464,0.0002319015,0.0003141784,0.0001176776,0.0001706393,0.001907128],"category_scores_gemma":[0.00008694464,0.0001231623,0.0002234296,0.00008561501,0.0001341507,0.0002118092,0.0002996238,0.0005026615,0.0007955449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945235,"about_ca_system_score_gemma":0.0001384323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003198274,"about_ca_topic_score_gemma":0.0005250798,"domain_scores_codex":[0.9998865,0.00001466086,0.000004120912,0.00001993017,0.00002385998,0.0000508862],"domain_scores_gemma":[0.9999404,0.000006564247,0.00001330301,0.000006136866,0.000006829201,0.00002679026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001259264,0.00002367898,0.0002301067,0.00003513946,0.000003662961,0.00006479133,0.00001185919,0.00004873665,0.9982257,0.0001941918,0.00009114067,0.0009450546],"study_design_scores_gemma":[0.00001250318,0.00008814032,0.008958543,0.000004321859,0.000006245011,0.0002652303,0.0000356587,0.00177205,0.9858878,0.00008760416,0.002878125,0.000003772296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995164,0.0008372631,0.001240473,0.0001306141,0.00001775448,0.000008412714,0.0001742539,0.00005435156,0.002372776],"genre_scores_gemma":[0.9967063,0.000342309,0.0004265311,0.00002524402,0.000005134781,0.00001260244,0.0003086275,0.000009337795,0.00216396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001907128,"threshold_uncertainty_score":0.006380022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005614803307542617,"score_gpt":0.220962662831114,"score_spread":0.2153478595235714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}