{"id":"W4301394819","doi":"10.1101/2022.10.03.510264","title":"AKIR-1 Regulates Proteasome Localization and Function in <i>Caenorhabditis elegans</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of British Columbia; Sigrid Juséliuksen Säätiö; Suomen Kulttuurirahasto; Agencia Estatal de Investigación; Helsingin Yliopisto; Ministerio de Ciencia, Innovación y Universidades; Academy of Finland; Medicinska Understödsföreningen Liv och Hälsa","keywords":"Proteasome; Caenorhabditis elegans; Cell biology; Biology; Proteostasis; Ubiquitin; Subcellular localization; RNA interference; Nuclear localization sequence; Cytoplasm; Protein degradation; Multicellular organism; F-box protein; Gene; Ubiquitin ligase; Biochemistry; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168489,0.0005573077,0.00021003,0.0003024124,0.0003496344,0.0003487135,0.0004281003,0.0003869348,0.001093047],"category_scores_gemma":[0.00008527792,0.0002432971,0.0002536461,0.0000809569,0.0002945898,0.0001583051,0.0002997232,0.0006210766,0.0005473551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009051003,"about_ca_system_score_gemma":0.0002958395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003027643,"about_ca_topic_score_gemma":0.006481919,"domain_scores_codex":[0.9998401,0.00001079489,0.00001415898,0.00005670638,0.00004454527,0.0000335726],"domain_scores_gemma":[0.9998034,0.00001735882,0.00008693344,0.00001502374,0.00002187063,0.00005543026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003069459,0.0000112723,0.0001371658,0.00001633078,0.00000223439,0.00004576439,0.000004423042,0.00004159145,0.9992519,0.00004031282,0.00006752092,0.0003507737],"study_design_scores_gemma":[0.00002555554,0.00007354344,0.01688121,0.00001962824,0.00002230013,0.0002830037,0.00003060389,0.002602358,0.9767868,0.00005770256,0.00320314,0.00001419606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922219,0.001348391,0.002608025,0.0001626154,0.00004874847,0.00002760302,0.001030604,0.000335042,0.002217063],"genre_scores_gemma":[0.9904875,0.0003955746,0.002465288,0.0001329251,0.000009821801,0.00003633916,0.0008685731,0.0001469485,0.005457069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003027643,"threshold_uncertainty_score":0.006566942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006465647780164475,"score_gpt":0.19273044939741,"score_spread":0.1862648016172455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}