{"id":"W4301395042","doi":"10.1101/2022.10.02.510508","title":"The scaffold proteins Tanc1 and Tanc2 are required for myoblast fusion","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; University of Texas Southwestern Medical Center","keywords":"Myogenesis; C2C12; Cell fusion; Myocyte; Cell biology; Fusion protein; Biology; Gene knockdown; Scaffold protein; Fusion; Cell; Genetics; Cell culture; Signal transduction; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492989,0.0006188181,0.0003391576,0.0004338507,0.0003251889,0.000478357,0.0002950108,0.0005087298,0.002221814],"category_scores_gemma":[0.0002138302,0.0003828576,0.0002940965,0.0002300711,0.0003267412,0.0002436637,0.0005725008,0.0005566648,0.001010417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005283983,"about_ca_system_score_gemma":0.0004625388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001789427,"about_ca_topic_score_gemma":0.002485638,"domain_scores_codex":[0.9998149,0.00001414392,0.00001567893,0.00005008529,0.00006444574,0.00004063201],"domain_scores_gemma":[0.9997454,0.00003820284,0.00006632447,0.000028984,0.00003540484,0.00008563956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008368474,0.000007027662,0.0003495921,0.00003930642,0.000004506806,0.0001399045,0.00001065004,0.00006054167,0.9984891,0.0001197351,0.00008945892,0.0006064074],"study_design_scores_gemma":[0.00002819554,0.0000334492,0.01771052,0.0000105743,0.00001677785,0.0009313588,0.00004901213,0.002598297,0.9734148,0.00008627299,0.0051093,0.00001131822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892498,0.002174515,0.003306199,0.0001841102,0.00007630605,0.00002703267,0.00170773,0.0002945141,0.002979826],"genre_scores_gemma":[0.9883361,0.0005040501,0.002408691,0.00007384287,0.00001142372,0.00003040829,0.002704626,0.0001407355,0.005789924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221814,"threshold_uncertainty_score":0.007432759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045502324966872,"score_gpt":0.2214723152668035,"score_spread":0.2110172920171348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}