{"id":"W4301399649","doi":"10.1016/j.bja.2022.08.026","title":"Remifentanil pharmacodynamics during conscious sedation using algometry: a more clinically relevant pharmacodynamical model","year":2022,"lang":"en","type":"article","venue":"British Journal of Anaesthesia","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Remifentanil; Medicine; Anesthesia; Midazolam; Sedation; Pharmacodynamics; Bolus (digestion); Propofol; Pharmacokinetics; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001019761,0.0002085875,0.000617231,0.0002874847,0.0004185227,0.0000526335,0.0002980209,0.00007863476,0.000199504],"category_scores_gemma":[0.0001760683,0.000243857,0.0003663536,0.0004352404,0.0001367694,0.0002580658,0.00009706106,0.001058676,0.00000317052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005275368,"about_ca_system_score_gemma":0.0004844491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003455997,"about_ca_topic_score_gemma":0.000001755401,"domain_scores_codex":[0.9969244,0.0002609697,0.001151942,0.0002962406,0.0009922936,0.0003741799],"domain_scores_gemma":[0.9983239,0.00006615891,0.0007777392,0.0001635024,0.0003191025,0.0003495878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0158681,0.007769138,0.2298912,0.000640205,0.002455838,0.1827957,0.003205969,0.1465637,0.2550335,0.0002590389,0.008388486,0.147129],"study_design_scores_gemma":[0.008696009,0.001079591,0.02316094,0.0003710999,0.000876424,0.1108284,0.00124453,0.8517919,0.0003306324,0.0001641689,0.0009736784,0.0004827184],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938833,0.0006027169,0.004023992,0.0009420029,0.0001319799,0.0002761866,0.00002534363,0.00003453468,0.00007994957],"genre_scores_gemma":[0.9869367,0.001116088,0.009568841,0.001938074,0.0001778393,0.000005041639,0.00002822443,0.00006512569,0.0001640328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7052281,"threshold_uncertainty_score":0.9944201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02569548596496564,"score_gpt":0.3219267172564747,"score_spread":0.2962312312915091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}