{"id":"W4301600257","doi":"10.1007/s11523-022-00920-y","title":"Do Early Phase Oncology Trials Predict Clinical Efficacy in Subsequent Biomarker-Enriched Phase III Randomized Trials?","year":2022,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Canadian Centre for Applied Research in Cancer Control; Sunnybrook Hospital","funders":"","keywords":"Medicine; Randomized controlled trial; Clinical endpoint; Clinical trial; Internal medicine; Confidence interval; Biomarker; Surrogate endpoint; Phases of clinical research; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.3475305,0.0008539583,0.0192384,0.000851528,0.0003537282,0.00006998505,0.00142642,0.001463503,0.01545589],"category_scores_gemma":[0.7929523,0.000693264,0.003094685,0.001446985,0.00148685,0.0001235322,0.0008465128,0.003089912,0.00008584694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001451567,"about_ca_system_score_gemma":0.002093212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000109385,"about_ca_topic_score_gemma":0.00001725475,"domain_scores_codex":[0.6906247,0.2794322,0.02414229,0.002319152,0.001584445,0.001897241],"domain_scores_gemma":[0.2685319,0.7212972,0.007500996,0.001472705,0.0003475185,0.0008496629],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6523542,0.03241088,0.00003855601,0.00005757272,0.002367164,0.00130078,0.000882368,0.00001626864,0.003575805,0.03448679,0.02069665,0.251813],"study_design_scores_gemma":[0.6296332,0.00883469,0.00004639401,0.00002503696,0.002057451,0.00004105792,0.0002188465,0.001266956,0.0001865909,0.3397211,0.01743689,0.0005316752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7979239,0.001716099,0.1368154,0.005346089,0.02248992,0.02627022,0.001817685,0.0009110622,0.006709646],"genre_scores_gemma":[0.6089014,0.0005955985,0.3805414,0.001598775,0.002491531,0.00506606,0.0001799728,0.0002417875,0.0003834417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4454218,"threshold_uncertainty_score":0.9998328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7138172971596959,"score_gpt":0.6583019463492661,"score_spread":0.0555153508104298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}