{"id":"W4301603215","doi":"10.1002/ar.25083","title":"Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet","year":2022,"lang":"en","type":"article","venue":"The Anatomical Record","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Intestinal epithelium; Mucin; Mucin 2; Citrobacter rodentium; Mucus; Intestinal permeability; Epithelium; Goblet cell; Gut flora; Intestinal mucosa; Immunology; Homeostasis; Microbiology; Gene expression; Immune system; Cell biology; Internal medicine; Gene; Genetics; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491158,0.0001398217,0.0001815329,0.00003312018,0.0002007176,0.00001487756,0.000295823,0.0001094669,0.00004307343],"category_scores_gemma":[0.00005124518,0.00008124795,0.0000654147,0.0001587222,0.000056097,0.000004307374,0.0001471431,0.0003433352,0.000003016818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006258178,"about_ca_system_score_gemma":0.00007613687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007347821,"about_ca_topic_score_gemma":0.000535076,"domain_scores_codex":[0.9986573,0.0004526438,0.0002082722,0.0002551237,0.0001662236,0.0002603911],"domain_scores_gemma":[0.999356,0.00007580656,0.0001631714,0.0003264064,0.00002910339,0.00004950764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008393152,0.0001170946,0.01415243,0.000008091072,0.000021424,0.000001210841,0.0002805011,0.0000063351,0.9804468,0.00002972648,0.003958638,0.0001384178],"study_design_scores_gemma":[0.003963654,0.005867156,0.3010749,0.00004641396,0.00009859724,0.00001204266,0.001968861,0.0000207384,0.6686025,0.0003300156,0.01748843,0.0005267157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989939,0.0001101041,0.00001459814,0.0003086821,0.0001175432,0.0003231601,0.00008431978,0.000006612858,0.00004111624],"genre_scores_gemma":[0.9989582,0.00003717992,0.00001119989,0.0006792143,0.00003490463,0.00004885165,0.0001294666,0.00001875811,0.0000821793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3118443,"threshold_uncertainty_score":0.3313195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009113910617892735,"score_gpt":0.2347429070699893,"score_spread":0.2256289964520966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}