{"id":"W4301603215","doi":"10.1002/ar.25083","title":"Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet","year":2022,"lang":"en","type":"article","venue":"The Anatomical Record","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Intestinal epithelium; Mucin; Mucin 2; Citrobacter rodentium; Mucus; Intestinal permeability; Epithelium; Goblet cell; Gut flora; Intestinal mucosa; Immunology; Homeostasis; Microbiology; Gene expression; Immune system; Cell biology; Internal medicine; Gene; Genetics; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548506,0.0005362565,0.0004238153,0.0009436687,0.000258763,0.0003272475,0.0001385447,0.0005358934,0.001798353],"category_scores_gemma":[0.0002132829,0.0003111748,0.0003909444,0.0003794128,0.0004299927,0.0002079612,0.0002991745,0.0007851768,0.0003142378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895449,"about_ca_system_score_gemma":0.0002289614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079535,"about_ca_topic_score_gemma":0.00103095,"domain_scores_codex":[0.9998146,0.00002330999,0.00002346991,0.00004646364,0.00004084026,0.00005128162],"domain_scores_gemma":[0.9993932,0.00003990044,0.0002214547,0.00004958123,0.00003810927,0.0002577052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001241202,0.0001235858,0.003613946,0.00003864986,0.0000225684,0.0004820567,0.00003637209,0.00002830755,0.9934787,0.00002987253,0.00003265676,0.0008721018],"study_design_scores_gemma":[0.0001835131,0.002244821,0.5323404,0.000033045,0.0001246943,0.005919912,0.000337736,0.001269961,0.4559682,0.0001424636,0.001405399,0.00002993044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986886,0.0003628748,0.0003578933,0.00004534502,0.000008628708,0.00001425649,0.0002025445,0.00003529968,0.0002846342],"genre_scores_gemma":[0.9979412,0.0002925117,0.0004841458,0.0000530493,0.000006946619,0.0000233676,0.0003140234,0.00001958652,0.0008651876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798353,"threshold_uncertainty_score":0.006016135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009113910617892735,"score_gpt":0.2347429070699893,"score_spread":0.2256289964520966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}