{"id":"W4302007589","doi":"10.1261/rna.079356.122","title":"<i>E. coli</i> 6S RNA complexed to RNA polymerase maintains product RNA synthesis at low cellular ATP levels by initiation with non-canonical initiator nucleotides","year":2022,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of British Columbia; Simon Fraser University","funders":"Simon Fraser University","keywords":"Biology; RNA-dependent RNA polymerase; RNA; Nucleotide; RNA polymerase I; RNA polymerase; Molecular biology; Biochemistry; RNA editing; Small nuclear RNA; Polymerase; Five-prime cap; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004802384,0.0004229156,0.0004285935,0.0001027031,0.0006410476,0.00007128155,0.0005431297,0.0001310287,0.0009228869],"category_scores_gemma":[0.000148211,0.0004166943,0.0001690782,0.0002825253,0.0001016308,0.00001735137,0.0004299646,0.000205361,0.00008450979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732706,"about_ca_system_score_gemma":0.0002708024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009014658,"about_ca_topic_score_gemma":0.00002729725,"domain_scores_codex":[0.9970868,0.0003519922,0.0004652068,0.0008952237,0.0005546474,0.0006461737],"domain_scores_gemma":[0.9984578,0.000069191,0.000247302,0.0007834392,0.0001066162,0.0003356874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000608841,0.0002203087,0.00005670152,0.00004555434,0.0001207826,0.0000502023,0.0001489022,0.0000929844,0.9899046,0.00009745706,0.006306693,0.002346984],"study_design_scores_gemma":[0.0005822364,0.0006444384,0.0001835554,0.00005019334,0.00007323005,0.00002811185,0.0001725817,0.00003735912,0.9778811,0.00004087235,0.01971513,0.0005912377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991444,0.0004577375,0.002898771,0.001600087,0.0002353641,0.0009749416,0.0006917555,0.00005302376,0.001644332],"genre_scores_gemma":[0.993917,0.00004437153,0.001364182,0.002600166,0.0003343102,0.0005019161,0.0002416505,0.000119981,0.0008763853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01340844,"threshold_uncertainty_score":0.9999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292628023988454,"score_gpt":0.2243056691266666,"score_spread":0.211379388886782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}