{"id":"W4302009239","doi":"10.21203/rs.3.rs-2042183/v1","title":"A Pilot Study about the Effectiveness of High-Dose Donepezil in Cognitive Function and Neuropsychiatric Symptoms in Parkinson’s disease with Cognitive Impairment","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Donepezil; Dementia; Neurocognitive; Dementia with Lewy bodies; Medicine; Montreal Cognitive Assessment; Internal medicine; Parkinson's disease; Cognition; Psychology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001558106,0.000738991,0.001017147,0.0002871151,0.0004995796,0.0003520853,0.0005486236,0.0006467569,0.001265674],"category_scores_gemma":[0.001212808,0.0002781885,0.00103777,0.0002423368,0.0006739807,0.0005086406,0.0002732164,0.0008529571,0.0002668786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005276655,"about_ca_system_score_gemma":0.0007537676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386796,"about_ca_topic_score_gemma":0.001400738,"domain_scores_codex":[0.9994776,0.000253122,0.00005693439,0.00007288202,0.00005849676,0.0000810506],"domain_scores_gemma":[0.9986398,0.000444558,0.000151318,0.0001170631,0.0001263767,0.0005208726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.496534,0.3408068,0.04246375,0.0009038287,0.001126443,0.002162005,0.001308966,0.0006050417,0.05717086,0.00009923119,0.0005011969,0.05631792],"study_design_scores_gemma":[0.03484765,0.9119233,0.04909204,0.00001587108,0.0002602398,0.0003437095,0.0001314475,0.0002945032,0.002739435,0.00003024737,0.0003030715,0.00001831161],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994602,0.0001397556,0.00004041458,0.00001812907,0.00001091893,0.0001408639,0.00003133821,0.00000313853,0.0001552934],"genre_scores_gemma":[0.9991401,0.0001379189,0.0002065035,0.0000602472,0.00003460692,0.0001576531,0.00009745551,0.000001254401,0.0001641044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558106,"threshold_uncertainty_score":0.008240163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317093525232435,"score_gpt":0.3475194011885821,"score_spread":0.3143484659362578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}