{"id":"W4302009855","doi":"10.1016/j.tet.2022.133064","title":"Synthesis of psychotropic alkaloids from Galbulimima","year":2022,"lang":"en","type":"article","venue":"Tetrahedron","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Chemistry; Division of Graduate Education; National Institute of General Medical Sciences; National Institute of Mental Health; Concordia University of Edmonton; American Australian Association; Bristol-Myers Squibb; University of North Carolina at Chapel Hill; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Natural product; Chemical space; Perspective (graphical); Natural (archaeology); Drug discovery; Psychology; Cognitive science; Stereochemistry; Computer science; Artificial intelligence; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008796565,0.0005199359,0.0003308592,0.0008182992,0.0004584947,0.0002567552,0.000411362,0.0002981289,0.005367197],"category_scores_gemma":[0.000100146,0.0001947329,0.0002793963,0.0005689148,0.0002315873,0.0002581014,0.000418092,0.0005637901,0.001743169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961594,"about_ca_system_score_gemma":0.0004950251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131217,"about_ca_topic_score_gemma":0.004042061,"domain_scores_codex":[0.9999471,0.000006790086,0.00000420708,0.00001110591,0.00001208549,0.0000187873],"domain_scores_gemma":[0.999965,0.00000489589,0.000005720917,0.000004526421,0.000007228938,0.00001263348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003505329,0.0001443178,0.0002715968,0.001609333,0.00005033056,0.001090422,0.0003252114,0.002103572,0.9378217,0.006178986,0.001530337,0.04852366],"study_design_scores_gemma":[0.0002352519,0.002334075,0.005967899,0.0003070268,0.0001848943,0.001191793,0.0002600646,0.001730943,0.874496,0.005131462,0.1080441,0.0001164907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7278714,0.03122789,0.03992181,0.001259963,0.0007839915,0.0009417314,0.004461174,0.001124479,0.1924078],"genre_scores_gemma":[0.9595846,0.009644898,0.01056688,0.0004316108,0.00006483035,0.0001509773,0.0009089834,0.00008834012,0.01855889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005367197,"threshold_uncertainty_score":0.01795506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019670654327549,"score_gpt":0.2174949674063273,"score_spread":0.2072982608630518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}