{"id":"W4302011924","doi":"10.1021/acs.biochem.2c00465","title":"Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation","year":2022,"lang":"en","type":"article","venue":"Biochemistry","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; York University; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Protein subunit; Dimer; ATP synthase; Stereochemistry; Chemistry; ATP synthase gamma subunit; Transferase; Active site; Hydrogen–deuterium exchange; Binding site; Crystallography; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729829,0.0000740836,0.0001347133,0.00005477777,0.00005204074,0.000004609283,0.0001784202,0.00005753958,0.00002034282],"category_scores_gemma":[0.0000912071,0.00008326166,0.00003646857,0.0001274458,0.0001072413,0.000003380499,0.000511136,0.00007416336,1.028482e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001051694,"about_ca_system_score_gemma":0.00003448016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000157062,"about_ca_topic_score_gemma":0.00006258833,"domain_scores_codex":[0.9994149,0.00006439908,0.0001789509,0.000193856,0.00007981624,0.00006811831],"domain_scores_gemma":[0.9992357,0.00002889258,0.000142807,0.0005266765,0.00003164449,0.00003427389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003964535,0.00009570581,0.01151203,0.00002211796,0.00003268575,3.003179e-7,0.0000538717,0.000008513133,0.9866503,0.000006377934,0.0001962824,0.001382138],"study_design_scores_gemma":[0.0001740417,0.00002361448,0.001874039,0.00001179521,0.00003078591,0.00001038393,0.0004448302,0.0007810844,0.9945816,0.00002333146,0.001963954,0.0000804805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979446,0.001234079,0.00002127935,0.00009014198,0.00000378928,0.00004150578,0.000096009,0.000002931704,0.0005656432],"genre_scores_gemma":[0.9985815,0.0001629706,0.0003568011,0.0000095282,0.000007165305,0.00001521678,0.0006611695,0.000005846062,0.0001998196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009637988,"threshold_uncertainty_score":0.3395312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079176465854321,"score_gpt":0.2532608298421309,"score_spread":0.2424690651835877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}