{"id":"W4302011924","doi":"10.1021/acs.biochem.2c00465","title":"Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation","year":2022,"lang":"en","type":"article","venue":"Biochemistry","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; York University; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Protein subunit; Dimer; ATP synthase; Stereochemistry; Chemistry; ATP synthase gamma subunit; Transferase; Active site; Hydrogen–deuterium exchange; Binding site; Crystallography; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000356026,0.0002711913,0.0003858231,0.0001498354,0.0002616681,0.001130327,0.0005506536,0.0005434002,0.000836911],"category_scores_gemma":[0.0005381661,0.0002923183,0.0001991588,0.0001173395,0.0007568345,0.0008341601,0.0005153273,0.0005410954,0.0002763773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005056435,"about_ca_system_score_gemma":0.0002405945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004257879,"about_ca_topic_score_gemma":0.0003872691,"domain_scores_codex":[0.9996847,0.00005375948,0.00002506737,0.00009442454,0.00009107962,0.00005102715],"domain_scores_gemma":[0.9994084,0.0001426695,0.0001838349,0.00006852455,0.00005758516,0.000139087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546845,0.00004028849,0.003017711,0.00003492328,0.00001140903,0.000146826,0.0001129358,0.001033738,0.9891012,0.001169972,0.00003883466,0.005137328],"study_design_scores_gemma":[0.0000512678,0.0004896584,0.08291481,0.00003308413,0.00003501222,0.001060809,0.0006167719,0.04067483,0.865782,0.004318228,0.003930202,0.0000933215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991756,0.001374818,0.005525698,0.0001304641,0.000014163,0.000007196996,0.00004157374,0.00008913659,0.001060931],"genre_scores_gemma":[0.9988133,0.0001878774,0.0007290189,0.0000216646,0.000004368248,0.000003748241,0.00003041395,0.00001080786,0.0001988109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130327,"threshold_uncertainty_score":0.003668725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079176465854321,"score_gpt":0.2532608298421309,"score_spread":0.2424690651835877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}