{"id":"W4302011971","doi":"10.1126/sciadv.abo3932","title":"Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Beta cell; Transcription factor; Biology; Endoplasmic reticulum; Cell biology; Islet; Unfolded protein response; Activating transcription factor; Glucose homeostasis; Endocrinology; Internal medicine; Transcription (linguistics); Insulin; Gene; Insulin resistance; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002800073,0.00009097919,0.0001413542,0.0001189045,0.0009639024,0.00009016949,0.00005694023,0.00001469592,0.00009781598],"category_scores_gemma":[0.000033338,0.0000842573,0.00001832745,0.0002861335,0.0002921896,0.001414805,0.00004917391,0.0001387869,6.103447e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006411262,"about_ca_system_score_gemma":0.00004151606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073363,"about_ca_topic_score_gemma":0.00001123168,"domain_scores_codex":[0.9989728,0.0000402578,0.0001013072,0.0003283847,0.0003702093,0.0001870125],"domain_scores_gemma":[0.9996414,0.00004287457,0.00007025923,0.0001005859,0.00003370334,0.0001112179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002683177,0.00005644908,0.08109907,0.00005468051,0.000003340076,5.911648e-7,0.0002276274,0.000007415979,0.9120143,0.00003833696,0.00001019276,0.006461167],"study_design_scores_gemma":[0.001440213,0.0004058509,0.4343017,0.00007534949,0.00007856113,0.00001108455,0.002558698,0.0003394609,0.5588813,0.0005110303,0.001182588,0.0002142083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968045,0.001566909,0.0005977952,0.000118107,0.0002177769,0.0001532427,0.00001974145,0.00004254248,0.0004793373],"genre_scores_gemma":[0.9994315,0.00003372754,0.000186393,0.0001261115,0.00003140209,0.00001101512,0.000007770078,0.000005142384,0.0001669477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3532026,"threshold_uncertainty_score":0.7413656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110931778320559,"score_gpt":0.295171232325536,"score_spread":0.2740619145423305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}