{"id":"W4302024760","doi":"10.1016/j.joca.2022.09.009","title":"WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes","year":2022,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ZonMw; Medical Delta; Universiteit Leiden; Leids Universitair Medisch Centrum; European Commission; Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society","keywords":"Downregulation and upregulation; Cartilage; Chondrocyte; Osteoarthritis; Biology; SOX9; Gene expression; Chondrogenesis; Gene; Cell biology; Internal medicine; Endocrinology; Anatomy; Pathology; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452067,0.000410425,0.0002677226,0.0004250023,0.0001543248,0.000266667,0.0001084245,0.0002314639,0.001852527],"category_scores_gemma":[0.0001845312,0.0001504579,0.0003270217,0.0003063427,0.0001677583,0.00009122698,0.0002320045,0.0002213693,0.0002559498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136532,"about_ca_system_score_gemma":0.0001078478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000454643,"about_ca_topic_score_gemma":0.0007273767,"domain_scores_codex":[0.9998032,0.00003055649,0.00001625546,0.00006893501,0.00005610125,0.00002490513],"domain_scores_gemma":[0.9997823,0.00002424355,0.0001294077,0.00001464745,0.00001454568,0.0000349014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004690029,0.00002705653,0.01717009,0.00007117196,0.00007777123,0.0003594307,0.00002473428,0.0001388674,0.9797344,0.00007661319,0.00008275389,0.001768089],"study_design_scores_gemma":[0.0000583803,0.0007651976,0.6206888,0.00002876969,0.0002899707,0.005372007,0.0001429038,0.003576904,0.3646897,0.0002747411,0.004086326,0.00002622508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964206,0.0008138983,0.001729464,0.00004531021,0.0000117444,0.000007699207,0.0004514918,0.00003474413,0.0004850051],"genre_scores_gemma":[0.9968677,0.000346981,0.0009763602,0.0000387095,0.0000140702,0.00001732303,0.0004986632,0.00001339033,0.001226835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852527,"threshold_uncertainty_score":0.006197274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00612154507997166,"score_gpt":0.226168940185646,"score_spread":0.2200473951056744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}