{"id":"W4302027542","doi":"10.1158/1535-7163.mct-22-0004","title":"NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Oncode Institute; Janet D. Cottrelle Foundation; BC Cancer Foundation; China Scholarship Council; Ovarian Cancer Canada; VGH and UBC Hospital Foundation","keywords":"Trametinib; MEK inhibitor; Cancer research; KRAS; Gene knockdown; Selumetinib; Synthetic lethality; MAPK/ERK pathway; Medicine; Downregulation and upregulation; Ovarian cancer; Serous fluid; Cell culture; Biology; Cancer; Internal medicine; Mutant; Gene; Signal transduction; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003903683,0.0002056337,0.0002988667,0.00011634,0.0002217698,0.00002042787,0.0001448437,0.00004960309,0.0002488665],"category_scores_gemma":[0.00001196427,0.0001667901,0.0001644252,0.0006132202,0.00005662605,0.00002439483,0.00006970781,0.0002486124,0.000004388727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001054866,"about_ca_system_score_gemma":0.0006485788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005864534,"about_ca_topic_score_gemma":0.00006112953,"domain_scores_codex":[0.99817,0.000274267,0.0003072092,0.0003401175,0.000594528,0.0003139257],"domain_scores_gemma":[0.9990364,0.0001041666,0.0001365413,0.0004951389,0.0001154841,0.000112259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00447791,0.0004870085,0.001940927,0.00008980441,0.001131177,0.0003333817,0.005181744,0.02959631,0.9408147,0.0005143597,0.0005045942,0.01492806],"study_design_scores_gemma":[0.003767203,0.001635998,0.007848971,0.0002359748,0.0008357655,0.00005454577,0.0009994004,0.0004624775,0.9477003,0.0001937022,0.03592585,0.0003397687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669748,0.003579141,0.0008936431,0.02692472,0.0003612863,0.0009773071,0.0001266855,0.00004043956,0.0001219607],"genre_scores_gemma":[0.9828073,0.000192095,0.000420587,0.01559174,0.00008462465,0.0007052892,0.00001777235,0.00005843678,0.0001220965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03542126,"threshold_uncertainty_score":0.6801504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380773318638299,"score_gpt":0.302896464923908,"score_spread":0.2690887317375251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}