{"id":"W4302027542","doi":"10.1158/1535-7163.mct-22-0004","title":"NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition","year":2022,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Oncode Institute; Janet D. Cottrelle Foundation; BC Cancer Foundation; China Scholarship Council; Ovarian Cancer Canada; VGH and UBC Hospital Foundation","keywords":"Trametinib; MEK inhibitor; Cancer research; KRAS; Gene knockdown; Selumetinib; Synthetic lethality; MAPK/ERK pathway; Medicine; Downregulation and upregulation; Ovarian cancer; Serous fluid; Cell culture; Biology; Cancer; Internal medicine; Mutant; Gene; Signal transduction; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458597,0.0001539844,0.0002693266,0.0001555976,0.00009108155,0.0004819832,0.0001695552,0.0001683162,0.001750945],"category_scores_gemma":[0.0002218365,0.0001111502,0.0002085651,0.0001233341,0.0001260559,0.0001611469,0.0002383044,0.0005361622,0.0003167058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932191,"about_ca_system_score_gemma":0.0003526303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008058317,"about_ca_topic_score_gemma":0.00205471,"domain_scores_codex":[0.9998802,0.00001288862,0.00001421057,0.00001831942,0.00003764843,0.00003669495],"domain_scores_gemma":[0.9999024,0.00002285072,0.0000151176,0.00001208433,0.00001473225,0.00003272341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009002772,0.0001730903,0.002667689,0.0001813593,0.00002501562,0.00008644041,0.00004910336,0.0005198636,0.977853,0.0001705942,0.000437027,0.01693653],"study_design_scores_gemma":[0.000142787,0.002136358,0.02108719,0.00002500867,0.00006742445,0.0006752886,0.0001553036,0.00287336,0.962475,0.0001163306,0.01023313,0.00001284761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957482,0.00143146,0.0004357698,0.00009970822,0.00002236197,0.00002408697,0.0003287798,0.00005498665,0.001854742],"genre_scores_gemma":[0.9977764,0.0005423292,0.0002991843,0.00004770761,0.000003159173,0.00001428092,0.0003389498,0.000008225817,0.0009696022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750945,"threshold_uncertainty_score":0.005857527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380773318638299,"score_gpt":0.302896464923908,"score_spread":0.2690887317375251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}