{"id":"W4302028211","doi":"10.1016/j.fbr.2022.09.002","title":"Heme sensing and trafficking in fungi","year":2022,"lang":"en","type":"article","venue":"Fungal Biology Reviews","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation; Canadian Institute for Advanced Research","keywords":"Heme; Vacuole; Biology; Candida albicans; Endomembrane system; Cryptococcus neoformans; Endocytosis; Biochemistry; Fungal protein; Mitochondrion; Intracellular; Cell biology; Yeast; Saccharomyces cerevisiae; Endoplasmic reticulum; Microbiology; Enzyme; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005161537,0.00009504065,0.0004040234,0.00009164897,0.0001728425,0.00000340462,0.0000230118,0.00003338997,0.0001323626],"category_scores_gemma":[0.00009528395,0.00007391208,0.00006345737,0.0002106525,0.00004799191,0.00001411331,0.00008912897,0.0002727768,0.00001580156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000455566,"about_ca_system_score_gemma":0.00001480549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000399735,"about_ca_topic_score_gemma":0.00004819882,"domain_scores_codex":[0.9991685,0.0001746345,0.0002542401,0.0002003864,0.00003237326,0.0001698508],"domain_scores_gemma":[0.9997222,0.00006581415,0.00005094035,0.0001146217,0.00001226742,0.00003419297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008561441,0.0001342087,0.5574687,0.0002262908,0.00006424366,0.0000973159,0.0008413075,0.000007169198,0.02518672,0.0007294051,0.008604823,0.4065542],"study_design_scores_gemma":[0.0005580852,0.0004870737,0.04373143,0.00008237027,0.00004930866,0.0006023569,0.000213001,0.0002066242,0.00006234295,0.00006099455,0.9538053,0.0001410571],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7559611,0.2358562,0.00004240721,0.001061681,0.0004338499,0.0005959123,0.000009354155,0.00004582585,0.0059936],"genre_scores_gemma":[0.9875772,0.01006856,0.0004597367,0.001372918,0.0001032062,0.0000347474,0.00001501448,0.000008084427,0.0003605464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9452005,"threshold_uncertainty_score":0.3014047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04838773495686982,"score_gpt":0.3191909085165911,"score_spread":0.2708031735597213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}