{"id":"W4302287941","doi":"10.3324/haematol.2022.280653","title":"CD56<sup>bright</sup>CD16<sup>–</sup> natural killer cells as an important regulatory mechanism in chronic graft-<I>versus</i>-host disease","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Manitoba; CancerCare Manitoba; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"Perforin; Immunology; Granzyme B; Population; Biology; Interleukin 21; CD16; Natural killer cell; CD8; Cytotoxic T cell; Cancer research; Immune system; Medicine; CD3; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001729553,0.002148172,0.002669053,0.001381176,0.002574406,0.0002525233,0.002227891,0.001718397,0.03186437],"category_scores_gemma":[0.0004815622,0.00198096,0.001425383,0.001378428,0.001129823,0.001281684,0.001526686,0.003050214,0.004922894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001980034,"about_ca_system_score_gemma":0.001087529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001117963,"about_ca_topic_score_gemma":0.0004087878,"domain_scores_codex":[0.9869105,0.002632079,0.003105117,0.00329658,0.0008795811,0.003176101],"domain_scores_gemma":[0.9936737,0.0007240101,0.001568183,0.002927438,0.0005010611,0.0006055921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008586572,0.002514954,0.000226043,0.0002983795,0.001268262,0.002184771,0.002164817,0.0006259319,0.7142928,0.08684354,0.1800806,0.0009133903],"study_design_scores_gemma":[0.01161847,0.003286501,0.003618455,0.0003236477,0.0007883292,0.002280978,0.001273563,0.00352504,0.03871667,0.002428513,0.9284741,0.003665787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392343,0.02627866,0.0001494827,0.001472994,0.02073934,0.003235649,0.0002837636,0.001480098,0.007125671],"genre_scores_gemma":[0.9490887,0.001798326,0.000172217,0.001651324,0.0003777445,0.0007858961,0.002917086,0.0003005214,0.04290818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7483935,"threshold_uncertainty_score":0.9995776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101338901872905,"score_gpt":0.2253885953033709,"score_spread":0.2152547051160804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}