{"id":"W4302293779","doi":"10.1038/s41467-022-33309-6","title":"DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Manitoba; Public Health Agency of Canada","funders":"Defense Advanced Research Projects Agency; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Public Health Agency of Canada; Indiana University Bloomington; Purdue University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; U.S. Department of Defense","keywords":"Monoclonal antibody; In vivo; Antibody; Virology; Recombinant DNA; Coronavirus disease 2019 (COVID-19); Pharmacokinetics; Potency; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Titer; Ex vivo; 2019-20 coronavirus outbreak; Antigen; Computational biology; Immunology; Biology; In vitro; Pharmacology; Infectious disease (medical specialty); Outbreak; Disease; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243011,0.0003051455,0.0001783028,0.0001985112,0.00007339119,0.0002669038,0.0001155953,0.00026558,0.001285162],"category_scores_gemma":[0.0001849679,0.00007757708,0.0001110148,0.0001108553,0.0001313893,0.000210382,0.00009358138,0.0003622629,0.0002539062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664867,"about_ca_system_score_gemma":0.0001973598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287805,"about_ca_topic_score_gemma":0.0005609213,"domain_scores_codex":[0.9999,0.00001816194,0.000006526703,0.00002158955,0.00002925149,0.00002455209],"domain_scores_gemma":[0.9999462,0.000008946314,0.00001833122,0.00000416222,0.000009466155,0.00001290698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442224,0.00007032619,0.0001157345,0.00002585156,0.000005317217,0.00001210756,0.000007103194,0.0002052916,0.996399,0.00005319994,0.0000579493,0.002903848],"study_design_scores_gemma":[0.00002821328,0.00157576,0.001510098,0.000003743751,0.00001434694,0.0001278056,0.000009636968,0.001284714,0.993032,0.00002753293,0.002382571,0.000003556885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924694,0.001323318,0.003640998,0.0001008484,0.00003852713,0.00003163756,0.0002521685,0.0001101358,0.002032909],"genre_scores_gemma":[0.9938559,0.0006830855,0.002738123,0.00005030461,0.00001138011,0.00002133182,0.0004396277,0.0000204122,0.002179893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285162,"threshold_uncertainty_score":0.004299283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05084336614167814,"score_gpt":0.3783922551176504,"score_spread":0.3275488889759723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}