{"id":"W4302303798","doi":"10.3389/fmed.2022.1003914","title":"Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing","year":2022,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Mitacs; Fonds de Recherche du Québec - Santé; Québec Consortium for Drug Discovery; Université de Sherbrooke","keywords":"Clear cell renal cell carcinoma; Sunitinib; Chorioallantoic membrane; Medicine; Drug; In vivo; Preclinical testing; Renal cell carcinoma; Oncology; Cancer research; Tyrosine-kinase inhibitor; Cancer; Internal medicine; Pharmacology; Angiogenesis; Biology; Medical physics; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007795592,0.0006263977,0.0005040805,0.0005811719,0.0004528087,0.0004682303,0.0004635655,0.0006803102,0.001096245],"category_scores_gemma":[0.0004143855,0.0002951343,0.0005672035,0.0003054491,0.0003065638,0.0004078866,0.0004066126,0.001379541,0.0007181081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007175707,"about_ca_system_score_gemma":0.0007821516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006245614,"about_ca_topic_score_gemma":0.00954293,"domain_scores_codex":[0.9994414,0.0001176882,0.00005676215,0.0001304835,0.0001725772,0.00008109839],"domain_scores_gemma":[0.9996107,0.0000903333,0.0000776951,0.00008481464,0.00006771836,0.00006876941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000121079,0.00006020664,0.0004827649,0.00008306947,0.0000129314,0.000198388,0.000071271,0.0002825279,0.9964014,0.0005036622,0.0002165077,0.001566207],"study_design_scores_gemma":[0.00004431227,0.0009639408,0.005767675,0.00004217941,0.00009571334,0.00179459,0.0001215711,0.006639132,0.9653988,0.0001886778,0.01890396,0.00003944006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8527842,0.009406367,0.1178874,0.0007361132,0.0005363232,0.001487927,0.005692866,0.0006795535,0.01078915],"genre_scores_gemma":[0.8801747,0.004734239,0.1027754,0.0002036497,0.00003116963,0.0008035949,0.005015361,0.0001014553,0.006160395],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.006245614,"threshold_uncertainty_score":0.01241851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009961186689355372,"score_gpt":0.2283935784449969,"score_spread":0.2184323917556416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}