{"id":"W4302362273","doi":"10.1111/jvh.13753","title":"A randomized phase 1b trial of the active site polymerase inhibitor nucleotide <scp>ATI</scp>‐2173 in patients with chronic hepatitis B virus infection","year":2022,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Tolerability; Medicine; Placebo; Adverse effect; Internal medicine; Hepatitis B virus; Immunology; Pharmacology; Virology; Gastroenterology; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561318,0.001178716,0.001999821,0.0003117997,0.000379909,0.0006594427,0.0004811465,0.001184267,0.005930749],"category_scores_gemma":[0.001087067,0.0005269118,0.001063355,0.0002549473,0.0006563241,0.0005752822,0.0002730448,0.00189614,0.0006845571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004543235,"about_ca_system_score_gemma":0.0009146603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984976,"about_ca_topic_score_gemma":0.001355011,"domain_scores_codex":[0.9995188,0.0002922834,0.00002496103,0.00007170771,0.0000289299,0.00006336148],"domain_scores_gemma":[0.9994248,0.0001537291,0.0001283001,0.00004477792,0.00004569725,0.0002026702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.976804,0.005325872,0.0005717773,0.0003897423,0.0004599116,0.0000387511,0.00003632907,0.0002167903,0.003853553,0.0001016557,0.0008191159,0.01138239],"study_design_scores_gemma":[0.9231198,0.07405388,0.001472225,0.0000151363,0.0001839537,0.0000295346,0.00001344273,0.0002819589,0.0003021702,0.00007426024,0.0004446987,0.000008894244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885075,0.002954531,0.0004370522,0.0004436522,0.0004620397,0.004342386,0.0008264417,0.0001067869,0.001919631],"genre_scores_gemma":[0.9890389,0.001696125,0.001132056,0.000910693,0.0003455447,0.003502291,0.001029771,0.00001888906,0.002325616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005930749,"threshold_uncertainty_score":0.01984036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008560298899872632,"score_gpt":0.260048190061726,"score_spread":0.2514878911618533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}