{"id":"W4302424689","doi":"10.1101/2022.10.04.510850","title":"Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Medical Research Council; Medizinischen Hochschule Hannover; Deutsche Forschungsgemeinschaft; Multiple Sclerosis Society","keywords":"Remyelination; Astrocyte; Oligodendrocyte; Central nervous system; Regeneration (biology); Neuroscience; Myelin; Astrogliosis; Biology; Neuroglia; Downregulation and upregulation; Stimulation; Nervous system; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857888,0.0002994972,0.0003072072,0.0002624424,0.0002675297,0.0004890521,0.0001686876,0.0002724171,0.001515314],"category_scores_gemma":[0.00007798376,0.00009929219,0.0001458093,0.0001207509,0.0003559483,0.0002098425,0.0004009695,0.0005278871,0.0007855922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876263,"about_ca_system_score_gemma":0.0002972562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005526259,"about_ca_topic_score_gemma":0.0008684696,"domain_scores_codex":[0.9999021,0.00001345425,0.000005552884,0.00001976002,0.00003647104,0.00002257173],"domain_scores_gemma":[0.9999315,0.000004829874,0.00002351085,0.000005455767,0.00001439966,0.00002029595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113228,0.00001918035,0.0004642393,0.0001465745,0.000008749087,0.000164719,0.00004188866,0.0001160637,0.9912169,0.001449022,0.0006878626,0.005571573],"study_design_scores_gemma":[0.00002131569,0.000178451,0.01636012,0.00005659923,0.00003171086,0.0008108514,0.000135499,0.002361908,0.9524858,0.002545314,0.02499833,0.00001412194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895507,0.06472415,0.0216562,0.001814258,0.0004799752,0.0000781874,0.001422551,0.001030019,0.01924402],"genre_scores_gemma":[0.9748461,0.009802259,0.004447355,0.0001577046,0.00008663061,0.00003634259,0.0005670827,0.00007165176,0.009984992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515314,"threshold_uncertainty_score":0.005069196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305334662305265,"score_gpt":0.2237168168934993,"score_spread":0.2006634702704467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}