{"id":"W4302424714","doi":"10.1213/ane.0000000000006207","title":"Oral Dantrolene for Myopathic Symptoms in Malignant Hyperthermia–Susceptible Patients: A 25-Year Retrospective Cohort Study of Adverse Effects and Tolerability","year":2022,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Medicine; Dantrolene; myalgia; Adverse effect; Rhabdomyolysis; Malignant hyperthermia; Tolerability; Retrospective cohort study; Context (archaeology); Internal medicine; Anesthesia; Myopathy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008463153,0.0003117004,0.0006096752,0.0008035696,0.0005762733,0.0006925166,0.0004122397,0.0004671261,0.00138577],"category_scores_gemma":[0.001707087,0.0005075282,0.0008954488,0.001320578,0.0002586465,0.0006010042,0.0005047584,0.000535745,0.000282263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003663012,"about_ca_system_score_gemma":0.0003648013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004098362,"about_ca_topic_score_gemma":0.004503116,"domain_scores_codex":[0.9992848,0.0001494136,0.0001128375,0.0002056685,0.0001394189,0.0001080037],"domain_scores_gemma":[0.9984408,0.0002039147,0.0008738707,0.0001601956,0.0001457352,0.0001755487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001100008,0.00003129229,0.9989346,0.00001473941,0.00008404285,0.0001486174,0.00004861319,0.000009987471,0.000098202,0.000006007208,0.0000470569,0.0004669359],"study_design_scores_gemma":[0.00002157189,0.0002189526,0.9984377,0.0000120341,0.00009720439,0.0006806249,0.0002163798,0.00008249251,0.00004098939,0.000008047265,0.0001787085,0.000005387366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988554,0.0006001241,0.00005790984,0.00001672448,0.000004488592,0.00002074679,0.0002727011,0.000001691887,0.0001702078],"genre_scores_gemma":[0.9991762,0.0003291112,0.00005292594,0.0000359308,0.00001008293,0.00001704762,0.0003094885,0.000001960409,0.00006713303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004098362,"threshold_uncertainty_score":0.008149028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005074606158037899,"score_gpt":0.2166387156969133,"score_spread":0.2115641095388754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}